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10.1186/2051-5960-2-49 http://scihub22266oqcxt.onion/10.1186/2051-5960-2-49 C4035092!4035092 !24886907     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24886907 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Neuropathol+Commun 2014 ; 2 (ä): 49 Nephropedia Template TP {{tp|p=24886907 |t=2014. Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model |pdf=|usr=}}{{24886907 }} gab.com Text Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24886907 #FOAvip INTRODUCTION: Small vessel disease (SVD) of the brain is a leading cause of age- and hypertension-related cognitive decline and disability. Cerebral white matter changes are a consistent manifestation of SVD on neuroimaging, progressing silently for many years before becoming clinically evident. The pathogenesis of these changes remains poorly understood, despite their importance. In particular, their pathological correlate at early stages remains largely undefined. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), caused by dominant mutations of the NOTCH3 receptor, is regarded as a paradigm for the most common form of sporadic SVD. In this study, we used immunohistochemistry, confocal microscopy and electron microscopy, together with qualitative and quantitative analyses to assess oligodendroglial, axon and myelin damage in TgPAC-Notch3R169C mice, a model of preclinical CADASIL. RESULTS: The principal cerebral white matter changes in TgPAC-Notch3R169C mice are microvacuoles (? 1 ?m diameter) in the myelin sheaths associated with focal myelin degradation and occurring in the absence of oligodendrocyte loss. Half the damaged myelin sheaths still contain an apparently intact axon. Clearance of myelin debris appears inefficient, as demonstrated by the significant but mild microglial reaction, with occasional myelin debris either contacted or internalized by microglial cells. CONCLUSION: Our findings suggest that segmental intramyelinic oedema is an early, conspicuous white matter change in CADASIL. Brain white matter intramyelinic oedema is consistently found in patients and mouse models with compromised ion and water homeostasis. These data provide a starting point for novel mechanistic studies to investigate the pathogenesis of SVD-related white matter changes. Twit Text FOAVip Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24886907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24886907 #FOAvip English Wikipedia <ref>{{Cite pmid|24886907 }}</ref> Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model #MMPMID24886907 Cognat E ; Cleophax S ; Domenga-Denier V ; Joutel A Acta Neuropathol Commun 2014[Apr]; 2 (ä): 49 PMID24886907 show ga INTRODUCTION: Small vessel disease (SVD) of the brain is a leading cause of age- and hypertension-related cognitive decline and disability. Cerebral white matter changes are a consistent manifestation of SVD on neuroimaging, progressing silently for many years before becoming clinically evident. The pathogenesis of these changes remains poorly understood, despite their importance. In particular, their pathological correlate at early stages remains largely undefined. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), caused by dominant mutations of the NOTCH3 receptor, is regarded as a paradigm for the most common form of sporadic SVD. In this study, we used immunohistochemistry, confocal microscopy and electron microscopy, together with qualitative and quantitative analyses to assess oligodendroglial, axon and myelin damage in TgPAC-Notch3R169C mice, a model of preclinical CADASIL. RESULTS: The principal cerebral white matter changes in TgPAC-Notch3R169C mice are microvacuoles (? 1 ?m diameter) in the myelin sheaths associated with focal myelin degradation and occurring in the absence of oligodendrocyte loss. Half the damaged myelin sheaths still contain an apparently intact axon. Clearance of myelin debris appears inefficient, as demonstrated by the significant but mild microglial reaction, with occasional myelin debris either contacted or internalized by microglial cells. CONCLUSION: Our findings suggest that segmental intramyelinic oedema is an early, conspicuous white matter change in CADASIL. Brain white matter intramyelinic oedema is consistently found in patients and mouse models with compromised ion and water homeostasis. These data provide a starting point for novel mechanistic studies to investigate the pathogenesis of SVD-related white matter changes. |Age Factors [MESH] |Animals [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, Myelomonocytic/metabolism [MESH] |Axons/pathology/ultrastructure [MESH] |Basic Helix-Loop-Helix Transcription Factors/metabolism [MESH] |Brain Edema/*etiology/pathology [MESH] |CADASIL/*complications/genetics [MESH] |Calcium-Binding Proteins/metabolism [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Gene Expression Regulation [MESH] |Leukoencephalopathies/*etiology/*pathology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Microfilament Proteins/metabolism [MESH] |Microglia/metabolism/pathology [MESH] |Microscopy, Electron [MESH] |Mutation/genetics [MESH] |Myelin Sheath/pathology/ultrastructure [MESH] |Nerve Tissue Proteins/metabolism [MESH] |Oligodendrocyte Transcription Factor 2 [MESH] |Receptor, Notch3 [MESH] |Receptors, Notch/genetics [MESH]Early white matter changes in CADASIL: evidence of segmental intramyel(epmc).pdf DeepDyve Pubget Overpricing