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10.1093/jmcb/mju016 http://scihub22266oqcxt.onion/10.1093/jmcb/mju016 C4034728!4034728!24847103     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2014 ; 6 (3): 240-54 Nephropedia Template TP {{tp|p=24847103|t=2014. Aurora A orchestrates entosis by regulating a dynamic MCAK?TIP150 interaction |pdf=|usr=}}{{24847103}} gab.com Text Aurora A orchestrates entosis by regulating a dynamic MCAK TIP150 interaction JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24847103 #FOAvip Entosis, a cell-in-cell process, has been implicated in the formation of aneuploidy associated with an aberrant cell division control. Microtubule plus-end-tracking protein TIP150 facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics during cell division. Here we show that TIP150 cooperates with MCAK to govern entosis via a regulatory circuitry that involves Aurora A-mediated phosphorylation of MCAK. Our biochemical analyses show that MCAK forms an intra-molecular association, which is essential for TIP150 binding. Interestingly, Aurora A-mediated phosphorylation of MCAK modulates its intra-molecular association, which perturbs the MCAK?TIP150 interaction in vitro and inhibits entosis in vivo. To probe if MCAK?TIP150 interaction regulates microtubule plasticity to affect the mechanical properties of cells during entosis, we used an optical trap to measure the mechanical rigidity of live MCF7 cells. We find that the MCAK cooperates with TIP150 to promote microtubule dynamics and modulate the mechanical rigidity of the cells during entosis. Our results show that a dynamic interaction of MCAK?TIP150 orchestrated by Aurora A-mediated phosphorylation governs entosis via regulating microtubule plus-end dynamics and cell rigidity. These data reveal a previously unknown mechanism of Aurora A regulation in the control of microtubule plasticity during cell-in-cell processes. Twit Text FOAVip Aurora A orchestrates entosis by regulating a dynamic MCAK TIP150 interaction ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24847103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24847103 #FOAvip English Wikipedia <ref>{{Cite pmid|24847103}}</ref> Aurora A orchestrates entosis by regulating a dynamic MCAK?TIP150 interaction #MMPMID24847103 Xia P; Zhou J; Song X; Wu B; Liu X; Li D; Zhang S; Wang Z; Yu H; Ward T; Zhang J; Li Y; Wang X; Chen Y; Guo Z; Yao X J Mol Cell Biol 2014[Jun]; 6 (3): 240-54 PMID24847103show ga Entosis, a cell-in-cell process, has been implicated in the formation of aneuploidy associated with an aberrant cell division control. Microtubule plus-end-tracking protein TIP150 facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics during cell division. Here we show that TIP150 cooperates with MCAK to govern entosis via a regulatory circuitry that involves Aurora A-mediated phosphorylation of MCAK. Our biochemical analyses show that MCAK forms an intra-molecular association, which is essential for TIP150 binding. Interestingly, Aurora A-mediated phosphorylation of MCAK modulates its intra-molecular association, which perturbs the MCAK?TIP150 interaction in vitro and inhibits entosis in vivo. To probe if MCAK?TIP150 interaction regulates microtubule plasticity to affect the mechanical properties of cells during entosis, we used an optical trap to measure the mechanical rigidity of live MCF7 cells. We find that the MCAK cooperates with TIP150 to promote microtubule dynamics and modulate the mechanical rigidity of the cells during entosis. Our results show that a dynamic interaction of MCAK?TIP150 orchestrated by Aurora A-mediated phosphorylation governs entosis via regulating microtubule plus-end dynamics and cell rigidity. These data reveal a previously unknown mechanism of Aurora A regulation in the control of microtubule plasticity during cell-in-cell processes. äAurora A orchestrates entosis by regulating a dynamic MCAK?TIP150 inte(epmc).pdf DeepDyve Pubget Overpricing