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2014 ; 2014
(ä): 859793
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Time-related alteration in flow- (shear stress-) mediated remodeling in
resistance arteries from spontaneously hypertensive rats
#MMPMID24900916
Dumont O
; Kauffenstein G
; Guihot AL
; Guérineau NC
; Abraham P
; Loufrani L
; Henrion D
Int J Hypertens
2014[]; 2014
(ä): 859793
PMID24900916
show ga
Hypertension is a major risk factor for cardiovascular disorders. As
flow-mediated outward remodeling has a key role in postischemic
revascularization, we investigated this remodeling in mesenteric resistance
arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3
to 9 months. Sequential ligation of mesenteric resistance arteries allowed
modifying blood flow in vivo, thus exposing arteries to low, normal, or high
flow. After 1, 3, 8, or 24 weeks, arteries were isolated for in vitro study. High
flow (HF) induced outward hypertrophic remodeling in WKY rats after 1 week and
persisted until 24 weeks without change in wall to lumen ratio. In SHRs, diameter
increase was delayed, occurring only after 3 weeks. Nevertheless, it was reduced
at 8 weeks and no longer significant after 24 weeks. In parallel, media
cross-section area increased more with time in SHRs than in WKY rats and this was
associated with increased contractility and oxidative stress with decreased
NO-dependent relaxation. Low flow induced progressive inward remodeling until 24
weeks in both strains with excessive hypertrophy in SHRs. Thus, a chronic
increase in flow induced transitory diameter expansion and long-lasting
hypertrophy in SHRs. This could contribute to the higher susceptibility of
hypertensive subjects to ischemic diseases.