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2014 ; 89
(4
): 504-19
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Latest advances in chemotherapeutic, targeted, and immune approaches in the
treatment of metastatic melanoma
#MMPMID24684873
Shah DJ
; Dronca RS
Mayo Clin Proc
2014[Apr]; 89
(4
): 504-19
PMID24684873
show ga
Melanoma is the most dangerous form of skin cancer owing to its metastatic
potential and is an important public health concern. The melanoma incidence has
been increasing worldwide. Although potentially curable when diagnosed early,
metastatic melanoma carries a poor prognosis. Until recently, systemic therapy
for metastatic melanoma was ineffective, but the recent successes in the
development of new therapies for metastatic melanoma, such as mitogen-activated
protein kinase (MAPK) pathway inhibitors, anti-cytotoxic T-lymphocyte-associated
antigen-4 (CTLA-4), and programmed cell death protein 1 (PD-1)/programmed cell
death ligand 1 (PD-L1) pathway blocking antibodies, as well as combination
strategies of cytotoxic chemotherapy and inhibitors of angiogenesis, have all
yielded promising results, changing the continually evolving landscape of
therapeutic options for patients with this disease. The aim of this review was to
summarize the evolution of and recent advances in the treatment of metastatic
melanoma. Therefore, we conducted a comprehensive PubMed search between January
1, 1960, and February 1, 2014, using the search term melanoma or metastatic
melanoma combined with terms such as chemotherapy, immunotherapy, CTLA-4, PD-1,
PD-L1, adoptive T cell, targeted therapy, MAPK, molecular biology, and survival.
|Antibodies, Monoclonal/immunology/therapeutic use
[MESH]
|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
[MESH]
|Disease-Free Survival
[MESH]
|Female
[MESH]
|Forecasting
[MESH]
|Humans
[MESH]
|Immunotherapy/*methods
[MESH]
|Male
[MESH]
|Melanoma/mortality/*secondary/*therapy
[MESH]
|Molecular Targeted Therapy/*methods
[MESH]
|Neoplasm Invasiveness/pathology
[MESH]
|Neoplasm Staging
[MESH]
|Prognosis
[MESH]
|Programmed Cell Death 1 Receptor/drug effects
[MESH]
free
free
free
