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10.1242/dev.107052 http://scihub22266oqcxt.onion/10.1242/dev.107052 C4034426!4034426!24866114     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2014 ; 141 (11): 2195-205 Nephropedia Template TP {{tp|p=24866114|t=2014. Switching on sex: transcriptional regulation of the testis-determining gene Sry |pdf=|usr=}}{{24866114}} gab.com Text Switching on sex: transcriptional regulation of the testis-determining gene Sry JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=24866114 #FOAvip Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y (Sry). Reduced or delayed Sry expression impairs testis development, highlighting the importance of its accurate spatiotemporal regulation and implying a potential role for SRY dysregulation in human intersex disorders. Several epigenetic modifiers, transcription factors and kinases are implicated in regulating Sry transcription, but it remains unclear whether or how this farrago of factors acts co-ordinately. Here we review our current understanding of Sry regulation and provide a model that assembles all known regulators into three modules, each converging on a single transcription factor that binds to the Sry promoter. We also discuss potential future avenues for discovering the cis-elements and trans-factors required for Sry regulation. Twit Text FOAVip Switching on sex: transcriptional regulation of the testis-determining gene Sry ????Development http://www.kidney.de/pget.php?&tw=1&pmid=24866114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24866114 #FOAvip English Wikipedia <ref>{{Cite pmid|24866114}}</ref> Switching on sex: transcriptional regulation of the testis-determining gene Sry #MMPMID24866114 Larney C; Bailey TL; Koopman P Development 2014[Jun]; 141 (11): 2195-205 PMID24866114show ga Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y (Sry). Reduced or delayed Sry expression impairs testis development, highlighting the importance of its accurate spatiotemporal regulation and implying a potential role for SRY dysregulation in human intersex disorders. Several epigenetic modifiers, transcription factors and kinases are implicated in regulating Sry transcription, but it remains unclear whether or how this farrago of factors acts co-ordinately. Here we review our current understanding of Sry regulation and provide a model that assembles all known regulators into three modules, each converging on a single transcription factor that binds to the Sry promoter. We also discuss potential future avenues for discovering the cis-elements and trans-factors required for Sry regulation. äSwitching on sex: transcriptional regulation of the testis-determining(epmc).pdf DeepDyve Pubget Overpricing