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2014 ; 2014
(ä): 595493
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Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor
cells, and stem cell therapy
#MMPMID24895592
Maeshima A
; Nakasatomi M
; Nojima Y
Biomed Res Int
2014[]; 2014
(ä): 595493
PMID24895592
show ga
The kidney has the capacity for regeneration and repair after a variety of
insults. Over the past few decades, factors that promote repair of the injured
kidney have been extensively investigated. By using kidney injury animal models,
the role of intrinsic and extrinsic growth factors, transcription factors, and
extracellular matrix in this process has been examined. The identification of
renal stem cells in the adult kidney as well as in the embryonic kidney is an
active area of research. Cell populations expressing putative stem cell markers
or possessing stem cell properties have been found in the tubules, interstitium,
and glomeruli of the normal kidney. Cell therapies with bone marrow-derived
hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells,
and amniotic fluid-derived stem cells have been highly effective for the
treatment of acute or chronic renal failure in animals. Embryonic stem cells and
induced pluripotent stem cells are also utilized for the construction of
artificial kidneys or renal components. In this review, we highlight the advances
in regenerative medicine for the kidney from the perspective of renotropic
factors, renal stem/progenitor cells, and stem cell therapies and discuss the
issues to be solved to realize regenerative therapy for kidney diseases in
humans.
|*Stem Cell Transplantation
[MESH]
|Animals
[MESH]
|Humans
[MESH]
|Intercellular Signaling Peptides and Proteins/*metabolism
[MESH]