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2014 ; 2014
(ä): 691260
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DNA Cleavage, Cytotoxic Activities, and Antimicrobial Studies of Ternary
Copper(II) Complexes of Isoxazole Schiff Base and Heterocyclic Compounds
#MMPMID24895493
Chityala VK
; Sathish Kumar K
; Macha R
; Tigulla P
; Shivaraj
Bioinorg Chem Appl
2014[]; 2014
(ä): 691260
PMID24895493
show ga
Novel mixed ligand bivalent copper complexes [Cu. L. A. ClO 4 ] and [Cu. L. A]
where "L" is Schiff bases, namely
2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-bromophenol
(DMIIMBP)/2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-chlorophenol (DMIIMCP),
and "A" is heterocyclic compound, such as 1,10-phenanthroline
(phen)/2,2(1)-bipyridyl (bipy)/8-hydroxyquinoline
(oxine)/5-chloro-8-hydroxyquinoline (5-Cl-oxine), have been synthesized. These
complexes have been characterized by IR, UV-Vis, ESR, elemental analysis,
magnetic moments, TG, and DTA. On the basis of spectral studies and analytical
data, five-coordinated square pyramidal/four-coordinated square planar geometry
is assigned to all complexes. The ligands and their ternary complexes with Cu(II)
have been screened for antimicrobial activity against bacteria and fungi by paper
disc method. The antimicrobial studies of Schiff bases and their metal complexes
showed significant activity and further it is observed that the metal complexes
showed more activity than corresponding Schiff bases. In vitro antitumor activity
of Cu(II) complexes was assayed against human cervical carcinoma (HeLa) cancer
cells and it was observed that few complexes exhibit good antitumor activity on
HeLa cell lines. The DNA cleavage studies have also been carried out on pBR 322
and it is observed that these Cu(II) complexes are capable of cleaving
supercoiled plasmid DNA in the presence of H2O2 and UV light.