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10.1016/j.surg.2014.01.013 http://scihub22266oqcxt.onion/10.1016/j.surg.2014.01.013 C4034135!4034135!24856127     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Surgery 2014 ; 155 (6): 1069-80 Nephropedia Template TP {{tp|p=24856127|t=2014. Heparin-binding EGF-like Growth Factor Restores Wnt/?-catenin Signaling in Intestinal Stem Cells Exposed to Ischemia/Reperfusion Injury |pdf=|usr=}}{{24856127}} gab.com Text Heparin-binding EGF-like Growth Factor Restores Wnt/ -catenin Signaling in Intestinal Stem Cells Exposed to Ischemia/Reperfusion Injury JO: Surgery http://www.kidney.de/pget.php?&tw=1&pmid=24856127 #FOAvip Background: We have previously demonstrated that heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from injury in several different experimental animal models. In the current study, we investigated whether the ability of HB-EGF to protect the intestines from ischemia/reperfusion (I/R) injury was related to its effects on Wnt/?-catenin signaling in intestinal stem cells (ISC). Methods: LGR5-EGFP transgenic (TG) mice with fluorescently labeled ISC, as well as the same mice treated with intraluminal HB-EGF or genetically engineered to overexpress HB-EGF, were exposed to segmental mesenteric artery occlusion (sMAO) to the terminal ilium. Wnt/?-catenin signaling was evaluated using immunofluorescent staining and Western blotting. Results: LGR5 expression and Wnt/?-catenin signaling in the ISC of the terminal ilium of LGR5-EGFP TG mice was significantly reduced 24 h post sMAO. Intraluminal administration of HB-EGF or HB-EGF overexpression in these mice led to preservation of LGR5 expression and Wnt/?-catenin signaling. Conclusion: These data show that HB-EGF preserves Wnt/?-catenin signaling in ISC after I/R injury. Twit Text FOAVip Heparin-binding EGF-like Growth Factor Restores Wnt/ -catenin Signaling in Intestinal Stem Cells Exposed to Ischemia/Reperfusion Injury ????Surgery http://www.kidney.de/pget.php?&tw=1&pmid=24856127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24856127 #FOAvip English Wikipedia <ref>{{Cite pmid|24856127}}</ref> Heparin-binding EGF-like Growth Factor Restores Wnt/?-catenin Signaling in Intestinal Stem Cells Exposed to Ischemia/Reperfusion Injury #MMPMID24856127 Chen CL; Yang J; James IO; Zhang Hy; Besner GE Surgery 2014[Jun]; 155 (6): 1069-80 PMID24856127show ga Background: We have previously demonstrated that heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from injury in several different experimental animal models. In the current study, we investigated whether the ability of HB-EGF to protect the intestines from ischemia/reperfusion (I/R) injury was related to its effects on Wnt/?-catenin signaling in intestinal stem cells (ISC). Methods: LGR5-EGFP transgenic (TG) mice with fluorescently labeled ISC, as well as the same mice treated with intraluminal HB-EGF or genetically engineered to overexpress HB-EGF, were exposed to segmental mesenteric artery occlusion (sMAO) to the terminal ilium. Wnt/?-catenin signaling was evaluated using immunofluorescent staining and Western blotting. Results: LGR5 expression and Wnt/?-catenin signaling in the ISC of the terminal ilium of LGR5-EGFP TG mice was significantly reduced 24 h post sMAO. Intraluminal administration of HB-EGF or HB-EGF overexpression in these mice led to preservation of LGR5 expression and Wnt/?-catenin signaling. Conclusion: These data show that HB-EGF preserves Wnt/?-catenin signaling in ISC after I/R injury. äHeparin-binding EGF-like Growth Factor Restores Wnt/?-catenin Signalin(epmc).pdf DeepDyve Pubget Overpricing