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10.4049/jimmunol.1400280 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400280 C4033523!4033523!24771857     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (11): 5343-53 Nephropedia Template TP {{tp|p=24771857|t=2014. Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation |pdf=|usr=}}{{24771857}} gab.com Text Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip Although roles of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation are well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in regulating tissue inflammatory immune response in a murine liver partial warm ischemia model. Myeloid-specific PTEN knock-out (KO) resulted in liver protections from ischemia reperfusion injury (IRI) by deviating local innate immune response against IR toward the regulatory type: expressions of pro-inflammatory genes were selectively decreased and anti-inflammatory IL-10 was simultaneously increased in IR livers of PTEN KO mice, as compared with those of wild-type (WT) mice. PI3 kinase inhibitor and IL-10 neutralizing Abs, but not exogenous LPS, recreated liver IRI in these KO mice. At the cellular level, Kupffer cells, as well as peritoneal macrophages, isolated from KO mice expressed higher levels of M2 markers, and produced lower TNF-? and higher IL-10 in response to TLR ligands, than their WT counterparts. They had enhanced Stat3 and Stat6, but diminished Stat1 signaling pathway activations in response to TLR4 stimulation. Inactivation of KCs by gadolinium chloride enhanced pro-inflammatory immune activation and increased IRI in livers of myeloid PTEN KO mice. Thus, myeloid PTEN deficiency protects livers from IRI by facilitating M2 macrophage differentiation. Twit Text FOAVip Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip English Wikipedia <ref>{{Cite pmid|24771857}}</ref> Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation #MMPMID24771857 Yue S; Rao J; Zhu J; Busuttil RW; Kupiec-Weglinski JW; Lu L; Wang X; Zhai Y J Immunol 2014[Jun]; 192 (11): 5343-53 PMID24771857show ga Although roles of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation are well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in regulating tissue inflammatory immune response in a murine liver partial warm ischemia model. Myeloid-specific PTEN knock-out (KO) resulted in liver protections from ischemia reperfusion injury (IRI) by deviating local innate immune response against IR toward the regulatory type: expressions of pro-inflammatory genes were selectively decreased and anti-inflammatory IL-10 was simultaneously increased in IR livers of PTEN KO mice, as compared with those of wild-type (WT) mice. PI3 kinase inhibitor and IL-10 neutralizing Abs, but not exogenous LPS, recreated liver IRI in these KO mice. At the cellular level, Kupffer cells, as well as peritoneal macrophages, isolated from KO mice expressed higher levels of M2 markers, and produced lower TNF-? and higher IL-10 in response to TLR ligands, than their WT counterparts. They had enhanced Stat3 and Stat6, but diminished Stat1 signaling pathway activations in response to TLR4 stimulation. Inactivation of KCs by gadolinium chloride enhanced pro-inflammatory immune activation and increased IRI in livers of myeloid PTEN KO mice. Thus, myeloid PTEN deficiency protects livers from IRI by facilitating M2 macrophage differentiation. äMyeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Inju(epmc).pdf DeepDyve Pubget Overpricing