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10.4049/jimmunol.1400280 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400280 C4033523!4033523 !24771857     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24771857 &cmd=llinks): Failed to open stream: HTTP request failed! 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Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation |pdf=|usr=}}{{24771857 }} gab.com Text Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip Although the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation is well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in regulating tissue inflammatory immune response in a murine liver partial warm ischemia model. Myeloid-specific PTEN knockout (KO) resulted in liver protection from ischemia reperfusion injury (IRI) by deviating the local innate immune response against ischemia reperfusion toward the regulatory type: expression of proinflammatory genes was selectively decreased and anti-inflammatory IL-10 was simultaneously increased in ischemia reperfusion livers of PTEN KO mice compared with those of wild-type (WT) mice. PI3K inhibitor and IL-10-neutralizing Abs, but not exogenous LPS, recreated liver IRI in these KO mice. At the cellular level, Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower TNF-? and higher IL-10 in response to TLR ligands than did their WT counterparts. They had enhanced Stat3- and Stat6-signaling pathway activation, but diminished Stat1-signaling pathway activation, in response to TLR4 stimulation. Inactivation of Kupffer cells by gadolinium chloride enhanced proinflammatory immune activation and increased IRI in livers of myeloid PTEN KO mice. Thus, myeloid PTEN deficiency protects livers from IRI by facilitating M2 macrophage differentiation. Twit Text FOAVip Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24771857 #FOAvip English Wikipedia <ref>{{Cite pmid|24771857 }}</ref> Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation #MMPMID24771857 Yue S ; Rao J ; Zhu J ; Busuttil RW ; Kupiec-Weglinski JW ; Lu L ; Wang X ; Zhai Y J Immunol 2014[Jun]; 192 (11 ): 5343-5353 PMID24771857 show ga Although the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation is well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in regulating tissue inflammatory immune response in a murine liver partial warm ischemia model. Myeloid-specific PTEN knockout (KO) resulted in liver protection from ischemia reperfusion injury (IRI) by deviating the local innate immune response against ischemia reperfusion toward the regulatory type: expression of proinflammatory genes was selectively decreased and anti-inflammatory IL-10 was simultaneously increased in ischemia reperfusion livers of PTEN KO mice compared with those of wild-type (WT) mice. PI3K inhibitor and IL-10-neutralizing Abs, but not exogenous LPS, recreated liver IRI in these KO mice. At the cellular level, Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower TNF-? and higher IL-10 in response to TLR ligands than did their WT counterparts. They had enhanced Stat3- and Stat6-signaling pathway activation, but diminished Stat1-signaling pathway activation, in response to TLR4 stimulation. Inactivation of Kupffer cells by gadolinium chloride enhanced proinflammatory immune activation and increased IRI in livers of myeloid PTEN KO mice. Thus, myeloid PTEN deficiency protects livers from IRI by facilitating M2 macrophage differentiation. |Animals [MESH] |Antibodies, Neutralizing/immunology/pharmacology [MESH] |Cell Differentiation/genetics/*immunology [MESH] |Interleukin-10/antagonists & inhibitors/genetics/immunology [MESH] |Kupffer Cells/*immunology/pathology [MESH] |Liver/*immunology/pathology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |PTEN Phosphohydrolase [MESH] |Phosphatidylinositol 3-Kinases/genetics/immunology [MESH] |Reperfusion Injury/genetics/*immunology/pathology [MESH] |STAT Transcription Factors/genetics/immunology [MESH]Myeloid PTEN deficiency protects livers from ischemia reperfusion inju(epmc).pdf DeepDyve Pubget Overpricing