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Gender differences in metabolic disorders and related diseases in Spontaneously
Diabetic Torii-Lepr(fa) rats
#MMPMID24892034
Ohta T
; Katsuda Y
; Miyajima K
; Sasase T
; Kimura S
; Tong B
; Yamada T
J Diabetes Res
2014[]; 2014
(?): 841957
PMID24892034
show ga
The Spontaneously Diabetic Torii Lepr(fa) (SDT fatty) rat is a novel type 2
diabetic model wherein both male and female rats develop glucose and lipid
abnormalities from a young age. In this study, we investigated gender differences
in abnormalities and related complications in SDT fatty rats. Food intake was
higher in males compared to female rats; however, body weight was not different
between genders. Progression of diabetes, including increases in blood glucose
and declines in blood insulin, was observed earlier in male rats than in females,
and diabetic grade was more critical in male rats. Blood lipids tended to
increase in female rats. Gonadal dysfunction was observed in both male and female
rats with aging. Microangiopathies, such as nephropathy, retinopathy, neuropathy,
and osteoporosis, were seen in both genders, and pathological grade and
progression were more significant in males. Qualitative and quantitative changes
were observed for metabolic disease gender differences in SDT fatty rats. The SDT
fatty rat is a useful model for researching gender differences in metabolic
disorders and related diseases in diabetes with obesity.
|*Aging
[MESH]
|Animals
[MESH]
|Behavior, Animal
[MESH]
|Diabetes Mellitus, Type 2/blood/*complications/*epidemiology/physiopathology
[MESH]
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