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2014 ; 2014
(ä): 718683
Nephropedia Template TP
gab.com Text
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English Wikipedia
Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate
segmentation clock
#MMPMID24895605
Resende TP
; Andrade RP
; Palmeirim I
Biomed Res Int
2014[]; 2014
(ä): 718683
PMID24895605
show ga
All vertebrate species present a segmented body, easily observed in the
vertebrate column and its associated components, which provides a high degree of
motility to the adult body and efficient protection of the internal organs. The
sequential formation of the segmented precursors of the vertebral column during
embryonic development, the somites, is governed by an oscillating genetic
network, the somitogenesis molecular clock. Herein, we provide an overview of the
molecular clock operating during somite formation and its underlying molecular
regulatory mechanisms. Human congenital vertebral malformations have been
associated with perturbations in these oscillatory mechanisms. Thus, a better
comprehension of the molecular mechanisms regulating somite formation is required
in order to fully understand the origin of human skeletal malformations.