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10.1155/2014/718683

http://scihub22266oqcxt.onion/10.1155/2014/718683
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suck abstract from ncbi


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pmid24895605
      Biomed+Res+Int 2014 ; 2014 (ä): 718683
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  • Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock #MMPMID24895605
  • Resende TP ; Andrade RP ; Palmeirim I
  • Biomed Res Int 2014[]; 2014 (ä): 718683 PMID24895605 show ga
  • All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associated with perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.
  • |*Gene Regulatory Networks [MESH]
  • |Animals [MESH]
  • |Biological Clocks/*genetics [MESH]
  • |Embryonic Development/*genetics [MESH]
  • |Humans [MESH]
  • |Models, Genetic [MESH]
  • |Time Factors [MESH]


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