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10.1681/ASN.2013070810 http://scihub22266oqcxt.onion/10.1681/ASN.2013070810 C4033375!4033375 !24511132     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24511132 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2014 ; 25 (6 ): 1237-54 Nephropedia Template TP {{tp|p=24511132 |t=2014. Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy |pdf=|usr=}}{{24511132 }} gab.com Text Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24511132 #FOAvip Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)-forming enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH oxidase are expressed (Nox1, Nox2, and Nox4). Here we show that Nox4 is the main source of renal ROS in a mouse model of diabetic nephropathy induced by streptozotocin administration in ApoE(-/-) mice. Deletion of Nox4, but not of Nox1, resulted in renal protection from glomerular injury as evidenced by attenuated albuminuria, preserved structure, reduced glomerular accumulation of extracellular matrix proteins, attenuated glomerular macrophage infiltration, and reduced renal expression of monocyte chemoattractant protein-1 and NF-?B in streptozotocin-induced diabetic ApoE(-/-) mice. Importantly, administration of the most specific Nox1/4 inhibitor, GKT137831, replicated these renoprotective effects of Nox4 deletion. In human podocytes, silencing of the Nox4 gene resulted in reduced production of ROS and downregulation of proinflammatory and profibrotic markers that are implicated in diabetic nephropathy. Collectively, these results identify Nox4 as a key source of ROS responsible for kidney injury in diabetes and provide proof of principle for an innovative small molecule approach to treat and/or prevent chronic kidney failure. Twit Text FOAVip Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24511132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24511132 #FOAvip English Wikipedia <ref>{{Cite pmid|24511132 }}</ref> Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy #MMPMID24511132 Jha JC ; Gray SP ; Barit D ; Okabe J ; El-Osta A ; Namikoshi T ; Thallas-Bonke V ; Wingler K ; Szyndralewiez C ; Heitz F ; Touyz RM ; Cooper ME ; Schmidt HH ; Jandeleit-Dahm KA J Am Soc Nephrol 2014[Jun]; 25 (6 ): 1237-54 PMID24511132 show ga Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)-forming enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH oxidase are expressed (Nox1, Nox2, and Nox4). Here we show that Nox4 is the main source of renal ROS in a mouse model of diabetic nephropathy induced by streptozotocin administration in ApoE(-/-) mice. Deletion of Nox4, but not of Nox1, resulted in renal protection from glomerular injury as evidenced by attenuated albuminuria, preserved structure, reduced glomerular accumulation of extracellular matrix proteins, attenuated glomerular macrophage infiltration, and reduced renal expression of monocyte chemoattractant protein-1 and NF-?B in streptozotocin-induced diabetic ApoE(-/-) mice. Importantly, administration of the most specific Nox1/4 inhibitor, GKT137831, replicated these renoprotective effects of Nox4 deletion. In human podocytes, silencing of the Nox4 gene resulted in reduced production of ROS and downregulation of proinflammatory and profibrotic markers that are implicated in diabetic nephropathy. Collectively, these results identify Nox4 as a key source of ROS responsible for kidney injury in diabetes and provide proof of principle for an innovative small molecule approach to treat and/or prevent chronic kidney failure. |*Diabetes Mellitus, Experimental/drug therapy/enzymology/genetics [MESH] |*Diabetic Nephropathies/drug therapy/enzymology/genetics [MESH] |Albuminuria/drug therapy/enzymology/genetics [MESH] |Animals [MESH] |Apolipoproteins E/genetics/metabolism [MESH] |Cell Line, Transformed [MESH] |Disease Models, Animal [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Extracellular Matrix/metabolism [MESH] |Gene Silencing [MESH] |Glucose/pharmacology [MESH] |Humans [MESH] |Macrophages/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |NADH, NADPH Oxidoreductases/antagonists & inhibitors/genetics/metabolism [MESH] |NADPH Oxidase 1 [MESH] |NADPH Oxidase 4 [MESH] |NADPH Oxidases/*antagonists & inhibitors/genetics/metabolism [MESH] |Podocytes/cytology/*enzymology [MESH] |Pyrazoles/*pharmacology [MESH] |Pyrazolones [MESH] |Pyridines/*pharmacology [MESH] |Pyridones [MESH]Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 pr(epmc).pdf DeepDyve Pubget Overpricing