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10.1016/j.biocel.2013.02.011 http://scihub22266oqcxt.onion/10.1016/j.biocel.2013.02.011 C4033300!4033300!23454662     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23454662&cmd=llinks): Failed to open stream: HTTP request failed! 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The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with G?13 and activation of Serum Response Factor |pdf=|usr=}}{{23454662}} gab.com Text The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with G 13 and activation of Serum Response Factor JO: Int J Biochem Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=23454662 #FOAvip Tec family kinases play critical roles in the activation of immune cells. In particular, Itk is important for the activation of T cells via the T cell Receptor (TcR), however, molecules that cooperate with Itk to activate downstream targets remain little explored. Here we show that Itk interacts with the heterotrimeric G-protein ! subunit G?13 during TcR triggering. This interaction requires membrane localization of both partners, and is partially dependent on GDP-and GTP-bound states of G?13. Furthermore, we find that Itk interacts with G?13 via the zinc binding regions within its Tec homology domain. The interaction between Itk and G?13 also results in tyrosine phosphorylation of G?13, however this is not required for the interaction. Itk enhances G?13 mediated activation of Serum Response Factor (SRF) transcriptional activity dependent on its ability to interact with G?13, but its kinase activity is not required to enhance SRF activity. These data reveal a new pathway regulated by Itk in cells, and suggest cross talk between Itk and G-protein signaling downstream of the TcR. Twit Text FOAVip The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with G 13 and activation of Serum Response Factor ????Int J Biochem Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=23454662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23454662 #FOAvip English Wikipedia <ref>{{Cite pmid|23454662}}</ref> The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with G?13 and activation of Serum Response Factor #MMPMID23454662 Huang W; Morales JL; Gazivoda VP; Lai J; Qi Q; August A Int J Biochem Cell Biol 2013[Jun]; 45 (6): 1074-82 PMID23454662show ga Tec family kinases play critical roles in the activation of immune cells. In particular, Itk is important for the activation of T cells via the T cell Receptor (TcR), however, molecules that cooperate with Itk to activate downstream targets remain little explored. Here we show that Itk interacts with the heterotrimeric G-protein ! subunit G?13 during TcR triggering. This interaction requires membrane localization of both partners, and is partially dependent on GDP-and GTP-bound states of G?13. Furthermore, we find that Itk interacts with G?13 via the zinc binding regions within its Tec homology domain. The interaction between Itk and G?13 also results in tyrosine phosphorylation of G?13, however this is not required for the interaction. Itk enhances G?13 mediated activation of Serum Response Factor (SRF) transcriptional activity dependent on its ability to interact with G?13, but its kinase activity is not required to enhance SRF activity. These data reveal a new pathway regulated by Itk in cells, and suggest cross talk between Itk and G-protein signaling downstream of the TcR. äThe zinc-binding region of IL-2 inducible T cell kinase (Itk) is requi(epmc).pdf DeepDyve Pubget Overpricing