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10.1101/cshperspect.a016071 http://scihub22266oqcxt.onion/10.1101/cshperspect.a016071 C4031966!4031966!24890509     free     free     free       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (6): ä Nephropedia Template TP {{tp|p=24890509|t=2014. Origin of Spliceosomal Introns and Alternative Splicing |pdf=|usr=}}{{24890509}} gab.com Text Origin of Spliceosomal Introns and Alternative Splicing JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24890509 #FOAvip In this work we review the current knowledge on the prehistory, origins, and evolution of spliceosomal introns. First, we briefly outline the major features of the different types of introns, with particular emphasis on the nonspliceosomal self-splicing group II introns, which are widely thought to be the ancestors of spliceosomal introns. Next, we discuss the main scenarios proposed for the origin and proliferation of spliceosomal introns, an event intimately linked to eukaryogenesis. We then summarize the evidence that suggests that the last eukaryotic common ancestor (LECA) had remarkably high intron densities and many associated characteristics resembling modern intron-rich genomes. From this intron-rich LECA, the different eukaryotic lineages have taken very distinct evolutionary paths leading to profoundly diverged modern genome structures. Finally, we discuss the origins of alternative splicing and the qualitative differences in alternative splicing forms and functions across lineages. Twit Text FOAVip Origin of Spliceosomal Introns and Alternative Splicing ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24890509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24890509 #FOAvip English Wikipedia <ref>{{Cite pmid|24890509}}</ref> Origin of Spliceosomal Introns and Alternative Splicing #MMPMID24890509 Irimia M; Roy SW Cold Spring Harb Perspect Biol 2014[Jun]; 6 (6): ä PMID24890509show ga In this work we review the current knowledge on the prehistory, origins, and evolution of spliceosomal introns. First, we briefly outline the major features of the different types of introns, with particular emphasis on the nonspliceosomal self-splicing group II introns, which are widely thought to be the ancestors of spliceosomal introns. Next, we discuss the main scenarios proposed for the origin and proliferation of spliceosomal introns, an event intimately linked to eukaryogenesis. We then summarize the evidence that suggests that the last eukaryotic common ancestor (LECA) had remarkably high intron densities and many associated characteristics resembling modern intron-rich genomes. From this intron-rich LECA, the different eukaryotic lineages have taken very distinct evolutionary paths leading to profoundly diverged modern genome structures. Finally, we discuss the origins of alternative splicing and the qualitative differences in alternative splicing forms and functions across lineages. äOrigin of Spliceosomal Introns and Alternative Splicing (epmc).pdf DeepDyve Pubget Overpricing