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10.1101/cshperspect.a016907 http://scihub22266oqcxt.onion/10.1101/cshperspect.a016907 C4031961!4031961!24799353     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (6): ä Nephropedia Template TP {{tp|p=24799353|t=2014. Lysosomal Adaptation: How the Lysosome Responds to External Cues |pdf=|usr=}}{{24799353}} gab.com Text Lysosomal Adaptation: How the Lysosome Responds to External Cues JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24799353 #FOAvip Recent evidence indicates that the importance of the lysosome in cell metabolism and organism physiology goes far beyond the simple disposal of cellular garbage. This dynamic organelle is situated at the crossroad of the most important cellular pathways and is involved in sensing, signaling, and transcriptional mechanisms that respond to environmental cues, such as nutrients. Two main mediators of these lysosomal adaptation mechanisms are the mTORC1 kinase complex and the transcription factor EB (TFEB). These two factors are linked in a lysosome-to-nucleus signaling pathway that provides the lysosome with the ability to adapt to extracellular cues and control its own biogenesis. Modulation of lysosomal function by acting on TFEB has a profound impact on cellular clearance and energy metabolism and is a promising therapeutic target for a large variety of disease conditions. Twit Text FOAVip Lysosomal Adaptation: How the Lysosome Responds to External Cues ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24799353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24799353 #FOAvip English Wikipedia <ref>{{Cite pmid|24799353}}</ref> Lysosomal Adaptation: How the Lysosome Responds to External Cues #MMPMID24799353 Settembre C; Ballabio A Cold Spring Harb Perspect Biol 2014[Jun]; 6 (6): ä PMID24799353show ga Recent evidence indicates that the importance of the lysosome in cell metabolism and organism physiology goes far beyond the simple disposal of cellular garbage. This dynamic organelle is situated at the crossroad of the most important cellular pathways and is involved in sensing, signaling, and transcriptional mechanisms that respond to environmental cues, such as nutrients. Two main mediators of these lysosomal adaptation mechanisms are the mTORC1 kinase complex and the transcription factor EB (TFEB). These two factors are linked in a lysosome-to-nucleus signaling pathway that provides the lysosome with the ability to adapt to extracellular cues and control its own biogenesis. Modulation of lysosomal function by acting on TFEB has a profound impact on cellular clearance and energy metabolism and is a promising therapeutic target for a large variety of disease conditions. äLysosomal Adaptation: How the Lysosome Responds to External Cues (epmc).pdf DeepDyve Pubget Overpricing