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10.1101/cshperspect.a014423

http://scihub22266oqcxt.onion/10.1101/cshperspect.a014423
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C4031955!4031955!24890833
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suck abstract from ncbi

pmid24890833      Cold+Spring+Harb+Perspect+Med 2014 ; 4 (6): ä
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  • MYC and the Control of DNA Replication #MMPMID24890833
  • Dominguez-Sola D; Gautier J
  • Cold Spring Harb Perspect Med 2014[Jun]; 4 (6): ä PMID24890833show ga
  • The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC?s diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mechanisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.
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