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10.1053/j.gastro.2013.12.032 http://scihub22266oqcxt.onion/10.1053/j.gastro.2013.12.032 C4031195!4031195 !24389305     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24389305 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gastroenterology 2014 ; 146 (4 ): 914-28 Nephropedia Template TP {{tp|p=24389305 |t=2014. Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives |pdf=|usr=}}{{24389305 }} gab.com Text Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=24389305 #FOAvip Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of drug dose, route, or duration of administration. Furthermore, idiosyncratic DILI is not a single disease entity but rather a spectrum of rare diseases with varying clinical, histological, and laboratory features. The pathogenesis of DILI is not fully understood. Standardization of the DILI nomenclature and methods to assess causality, along with the information provided by the LiverTox Web site, will harmonize and accelerate research on DILI. Studies of new serum biomarkers such as glutamate dehydrogenase, high mobility group box protein 1, and microRNA-122 could provide information for use in diagnosis and prognosis and provide important insights into the mechanisms of the pathogenesis of DILI. Single nucleotide polymorphisms in the HLA region have been associated with idiosyncratic hepatotoxicity attributed to flucloxacillin, ximelagatran, lapatinib, and amoxicillin-clavulanate. However, genome-wide association studies of pooled cases have not associated any genetic factors with idiosyncratic DILI. Whole genome and whole exome sequencing analyses are under way to study cases of DILI attributed to a single medication. Serum proteomic, transcriptome, and metabolome as well as intestinal microbiome analyses will increase our understanding of the mechanisms of this disorder. Further improvements to in vitro and in vivo test systems should advance our understanding of the causes, risk factors, and mechanisms of idiosyncratic DILI. Twit Text FOAVip Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=24389305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24389305 #FOAvip English Wikipedia <ref>{{Cite pmid|24389305 }}</ref> Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives #MMPMID24389305 Fontana RJ Gastroenterology 2014[Apr]; 146 (4 ): 914-28 PMID24389305 show ga Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of drug dose, route, or duration of administration. Furthermore, idiosyncratic DILI is not a single disease entity but rather a spectrum of rare diseases with varying clinical, histological, and laboratory features. The pathogenesis of DILI is not fully understood. Standardization of the DILI nomenclature and methods to assess causality, along with the information provided by the LiverTox Web site, will harmonize and accelerate research on DILI. Studies of new serum biomarkers such as glutamate dehydrogenase, high mobility group box protein 1, and microRNA-122 could provide information for use in diagnosis and prognosis and provide important insights into the mechanisms of the pathogenesis of DILI. Single nucleotide polymorphisms in the HLA region have been associated with idiosyncratic hepatotoxicity attributed to flucloxacillin, ximelagatran, lapatinib, and amoxicillin-clavulanate. However, genome-wide association studies of pooled cases have not associated any genetic factors with idiosyncratic DILI. Whole genome and whole exome sequencing analyses are under way to study cases of DILI attributed to a single medication. Serum proteomic, transcriptome, and metabolome as well as intestinal microbiome analyses will increase our understanding of the mechanisms of this disorder. Further improvements to in vitro and in vivo test systems should advance our understanding of the causes, risk factors, and mechanisms of idiosyncratic DILI. |*Chemical and Drug Induced Liver Injury/blood/classification/diagnosis/epidemiology/genetics [MESH] |Animals [MESH] |Biomarkers/blood [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Liver/*drug effects/metabolism/pathology [MESH] |Pharmacogenetics [MESH] |Predictive Value of Tests [MESH] |Prognosis [MESH] |Registries [MESH] |Risk Factors [MESH]Pathogenesis of idiosyncratic drug-induced liver injury and clinical (epmc).pdf DeepDyve Pubget Overpricing