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10.3390/biom3040889

http://scihub22266oqcxt.onion/10.3390/biom3040889
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C4030976!4030976!24970195
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suck abstract from ncbi


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pmid24970195      Biomolecules 2013 ; 3 (4): 889-904
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  • Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors #MMPMID24970195
  • Schauer G; Leuba S; Sluis-Cremer N
  • Biomolecules 2013[Dec]; 3 (4): 889-904 PMID24970195show ga
  • HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucial clinical role in treating and preventing HIV-1 infection, their mechanism of action remains elusive. In this review, we introduce RT and highlight major advances from experimental and computational biophysical experiments toward an understanding of RT function and the inhibitory mechanism(s) of NNRTIs.
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