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10.3390/biom2040579 http://scihub22266oqcxt.onion/10.3390/biom2040579 C4030857!4030857!24970150     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2012 ; 2 (4): 579-607 Nephropedia Template TP {{tp|p=24970150|t=2012. Pathways for Genome Integrity in G2 Phase of the Cell Cycle |pdf=|usr=}}{{24970150}} gab.com Text Pathways for Genome Integrity in G2 Phase of the Cell Cycle JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970150 #FOAvip The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and cell cycle arrest. Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell. Here, we review recent progress in our understanding of DNA repair and checkpoint pathways in late S and G2 phases. This review will first describe the current understanding of normal cell cycle progression through G2 phase to mitosis. It will also discuss the DNA damage response including cell cycle checkpoint control and DNA double-strand break repair. Finally, we discuss the emerging concept that DNA repair pathways play a major role in the G2/M checkpoint pathway thereby blocking cell division as long as DNA lesions are present. Twit Text FOAVip Pathways for Genome Integrity in G2 Phase of the Cell Cycle ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24970150 #FOAvip English Wikipedia <ref>{{Cite pmid|24970150}}</ref> Pathways for Genome Integrity in G2 Phase of the Cell Cycle #MMPMID24970150 Kousholt AN; Menzel T; Sørensen CS Biomolecules 2012[Dec]; 2 (4): 579-607 PMID24970150show ga The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and cell cycle arrest. Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell. Here, we review recent progress in our understanding of DNA repair and checkpoint pathways in late S and G2 phases. This review will first describe the current understanding of normal cell cycle progression through G2 phase to mitosis. It will also discuss the DNA damage response including cell cycle checkpoint control and DNA double-strand break repair. Finally, we discuss the emerging concept that DNA repair pathways play a major role in the G2/M checkpoint pathway thereby blocking cell division as long as DNA lesions are present. äPathways for Genome Integrity in G2 Phase of the Cell Cycle (epmc).pdf DeepDyve Pubget Overpricing