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10.3390/biom2040635

http://scihub22266oqcxt.onion/10.3390/biom2040635
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suck abstract from ncbi


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pmid24970153
      Biomolecules 2012 ; 2 (4 ): 635-49
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  • Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy #MMPMID24970153
  • Ström CE ; Helleday T
  • Biomolecules 2012[Dec]; 2 (4 ): 635-49 PMID24970153 show ga
  • Treatments with Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors have offered patients carrying cancers with mutated BRCA1 or BRCA2 genes a new and in many cases effective option for disease control. There is potentially a large patient population that may also benefit from PARP inhibitor treatment, either in monotherapy or in combination with chemotherapy. Here, we describe the multifaceted role of PARP inhibitors and discuss which treatment options could potentially be useful to gain disease control without potentiating side effects.
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