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10.3390/biom2030350 http://scihub22266oqcxt.onion/10.3390/biom2030350 C4030836!4030836!24970142     free     free     free       Biomolecules 2012 ; 2 (3): 350-75 Nephropedia Template TP {{tp|p=24970142|t=2012. SUMO Wrestles with Recombination |pdf=|usr=}}{{24970142}} gab.com Text SUMO Wrestles with Recombination JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970142 #FOAvip DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. On the other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins involved in different steps of HR have been shown to undergo modification by small ubiquitin-like modifier (SUMO) peptide and it has been suggested that deficient sumoylation impairs the progression of HR. This review addresses specific effects of sumoylation on the properties of various HR proteins and describes its importance for the homeostasis of DNA repetitive sequences. The article further illustrates the role of sumoylation in meiotic recombination and the interplay between SUMO and other post-translational modifications. Twit Text FOAVip SUMO Wrestles with Recombination ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24970142 #FOAvip English Wikipedia <ref>{{Cite pmid|24970142}}</ref> SUMO Wrestles with Recombination #MMPMID24970142 Altmannová V; Kolesár P; Krej?í L Biomolecules 2012[Sep]; 2 (3): 350-75 PMID24970142show ga DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. On the other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins involved in different steps of HR have been shown to undergo modification by small ubiquitin-like modifier (SUMO) peptide and it has been suggested that deficient sumoylation impairs the progression of HR. This review addresses specific effects of sumoylation on the properties of various HR proteins and describes its importance for the homeostasis of DNA repetitive sequences. The article further illustrates the role of sumoylation in meiotic recombination and the interplay between SUMO and other post-translational modifications. äSUMO Wrestles with Recombination (epmc).pdf DeepDyve Pubget Overpricing