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10.1161/HYPERTENSIONAHA.113.03025 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.113.03025 C4030711!4030711!24711523     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2014 ; 63 (6): 1219-27 Nephropedia Template TP {{tp|p=24711523|t=2014. ANGIOTENSIN-(1-7) RECRUITS MUSCLE MICROVASCULATURE AND ENHANCES INSULIN?S METABOLIC ACTION VIA MAS RECEPTOR |pdf=|usr=}}{{24711523}} gab.com Text ANGIOTENSIN-(1-7) RECRUITS MUSCLE MICROVASCULATURE AND ENHANCES INSULIN S METABOLIC ACTION VIA MAS RECEPTOR JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=24711523 #FOAvip Angiotensin (Ang)-(1-7), an endogenous ligand for the G protein-coupled receptor Mas, exerts both vasodilatory and insulin sensitizing effects. In skeletal muscle relaxation of pre-capillary arterioles recruits microvasculature and increases the endothelial surface area available for nutrient and hormone exchanges.To assess whether Ang-(1-7) recruits microvasculature and enhances insulin action in muscle, overnight-fasted adult rats received an intravenous infusion of Ang-(1-7) (0, 10 or 100 ng/kg/min) for 150 min with or without a simultaneous infusion of the Mas inhibitor A-779 and a superimposition of a euglycemic insulin clamp (3 mU/kg/min) from 30 to 150 min. Hindlimb muscle microvascular blood volume (MBV), microvascular flow velocity (MFV) and microvascular blood flow (MBF) were determined. Myographic changes in tension were measured on pre-constricted distal saphenous artery.Ang-(1-7) dose-dependently relaxed the saphenous artery (p<0.05) ex vivo. This effect was potentiated by insulin (p<0.01) and abolished by either endothelium denudement or Mas inhibition. Systemic infusion of Ang-(1-7) rapidly increased muscle MBV and MBF (p<0.05, each) without altering MFV. Insulin infusion alone increased muscle MBV by 60?70% (p<0.05). Adding insulin to the Ang-(1-7) infusion further increased muscle MBV and MBF (~2.5 fold, p<0.01). These were associated with a significant increase in insulin-mediated glucose disposal and muscle Akt and ERK1/2 phosphorylation. A-779 pre-treatment blunted Ang-(1-7)?s microvascular and insulin-sensitizing effects.We conclude that Ang-(1-7) by activating Mas recruits muscle microvasculature and enhances insulin?s metabolic action. These effects may contribute to the cardiovascular protective responses associated with Mas activation and explain Ang-(1-7)?s insulin sensitizing action. Twit Text FOAVip ANGIOTENSIN-(1-7) RECRUITS MUSCLE MICROVASCULATURE AND ENHANCES INSULIN S METABOLIC ACTION VIA MAS RECEPTOR ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=24711523 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24711523 #FOAvip English Wikipedia <ref>{{Cite pmid|24711523}}</ref> ANGIOTENSIN-(1-7) RECRUITS MUSCLE MICROVASCULATURE AND ENHANCES INSULIN?S METABOLIC ACTION VIA MAS RECEPTOR #MMPMID24711523 Fu Z; Zhao L; Aylor KW; Carey RM; Barrett EJ; Liu Z Hypertension 2014[Jun]; 63 (6): 1219-27 PMID24711523show ga Angiotensin (Ang)-(1-7), an endogenous ligand for the G protein-coupled receptor Mas, exerts both vasodilatory and insulin sensitizing effects. In skeletal muscle relaxation of pre-capillary arterioles recruits microvasculature and increases the endothelial surface area available for nutrient and hormone exchanges.To assess whether Ang-(1-7) recruits microvasculature and enhances insulin action in muscle, overnight-fasted adult rats received an intravenous infusion of Ang-(1-7) (0, 10 or 100 ng/kg/min) for 150 min with or without a simultaneous infusion of the Mas inhibitor A-779 and a superimposition of a euglycemic insulin clamp (3 mU/kg/min) from 30 to 150 min. Hindlimb muscle microvascular blood volume (MBV), microvascular flow velocity (MFV) and microvascular blood flow (MBF) were determined. Myographic changes in tension were measured on pre-constricted distal saphenous artery.Ang-(1-7) dose-dependently relaxed the saphenous artery (p<0.05) ex vivo. This effect was potentiated by insulin (p<0.01) and abolished by either endothelium denudement or Mas inhibition. Systemic infusion of Ang-(1-7) rapidly increased muscle MBV and MBF (p<0.05, each) without altering MFV. Insulin infusion alone increased muscle MBV by 60?70% (p<0.05). Adding insulin to the Ang-(1-7) infusion further increased muscle MBV and MBF (~2.5 fold, p<0.01). These were associated with a significant increase in insulin-mediated glucose disposal and muscle Akt and ERK1/2 phosphorylation. A-779 pre-treatment blunted Ang-(1-7)?s microvascular and insulin-sensitizing effects.We conclude that Ang-(1-7) by activating Mas recruits muscle microvasculature and enhances insulin?s metabolic action. These effects may contribute to the cardiovascular protective responses associated with Mas activation and explain Ang-(1-7)?s insulin sensitizing action. äANGIOTENSIN-(1-7) RECRUITS MUSCLE MICROVASCULATURE AND ENHANCES INSULI(epmc).pdf DeepDyve Pubget Overpricing