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10.2337/db13-1604 http://scihub22266oqcxt.onion/10.2337/db13-1604 C4030109!4030109 !24458361     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24458361 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes 2014 ; 63 (6 ): 1920-32 Nephropedia Template TP {{tp|p=24458361 |t=2014. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-? |pdf=|usr=}}{{24458361 }} gab.com Text The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF- JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=24458361 #FOAvip Microfibril-associated glycoprotein 1 (MAGP1) is a component of extracellular matrix microfibrils. Here we show that MAGP1 expression is significantly altered in obese humans, and inactivation of the MAGP1 gene (Mfap2(-/-)) in mice results in adipocyte hypertrophy and predisposition to metabolic dysfunction. Impaired thermoregulation was evident in Mfap2(-/-) mice prior to changes in adiposity, suggesting a causative role for MAGP1 in the increased adiposity and predisposition to diabetes. By 5 weeks of age, Mfap2(-/-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the brown adipose tissue, and there was reduced browning of the subcutaneous white adipose tissue. Levels of transforming growth factor-? (TGF-?) activity were elevated in Mfap2(-/-) adipose tissue, and the treatment of Mfap2(-/-) mice with a TGF-?-neutralizing antibody improved their body temperature and prevented the increased adiposity phenotype. Together, these findings indicate that the regulation of TGF-? by MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction. Twit Text FOAVip The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF- ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=24458361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24458361 #FOAvip English Wikipedia <ref>{{Cite pmid|24458361 }}</ref> The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-? #MMPMID24458361 Craft CS ; Pietka TA ; Schappe T ; Coleman T ; Combs MD ; Klein S ; Abumrad NA ; Mecham RP Diabetes 2014[Jun]; 63 (6 ): 1920-32 PMID24458361 show ga Microfibril-associated glycoprotein 1 (MAGP1) is a component of extracellular matrix microfibrils. Here we show that MAGP1 expression is significantly altered in obese humans, and inactivation of the MAGP1 gene (Mfap2(-/-)) in mice results in adipocyte hypertrophy and predisposition to metabolic dysfunction. Impaired thermoregulation was evident in Mfap2(-/-) mice prior to changes in adiposity, suggesting a causative role for MAGP1 in the increased adiposity and predisposition to diabetes. By 5 weeks of age, Mfap2(-/-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the brown adipose tissue, and there was reduced browning of the subcutaneous white adipose tissue. Levels of transforming growth factor-? (TGF-?) activity were elevated in Mfap2(-/-) adipose tissue, and the treatment of Mfap2(-/-) mice with a TGF-?-neutralizing antibody improved their body temperature and prevented the increased adiposity phenotype. Together, these findings indicate that the regulation of TGF-? by MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction. |Adipocytes/*metabolism [MESH] |Adipose Tissue/*metabolism [MESH] |Animals [MESH] |Contractile Proteins/deficiency/*metabolism [MESH] |Diabetes Mellitus, Type 2/genetics/*metabolism [MESH] |Extracellular Matrix Proteins/deficiency/*metabolism [MESH] |Genetic Pleiotropy [MESH] |Genetic Predisposition to Disease [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Obesity/genetics/*metabolism [MESH] |Phenotype [MESH] |RNA Splicing Factors [MESH] |Signal Transduction [MESH] |Thermogenesis/genetics [MESH]The extracellular matrix protein MAGP1 supports thermogenesis and prot(epmc).pdf DeepDyve Pubget Overpricing