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10.1038/clpt.2014.51 http://scihub22266oqcxt.onion/10.1038/clpt.2014.51 C4029855!4029855!24577151     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Pharmacol+Ther 2014 ; 95 (6): 663-9 Nephropedia Template TP {{tp|p=24577151|t=2014. Integrating systems biology sources illuminates drug action |pdf=|usr=}}{{24577151}} gab.com Text Integrating systems biology sources illuminates drug action JO: Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24577151 #FOAvip There are significant gaps in our understanding of the pathways by which drugs act. This incomplete knowledge limits our ability to use mechanistic molecular information rationally to repurpose drugs, understand their side effects, and predict their interactions with other drugs. Here we present DrugRouter: a novel method for generating drug-specific pathways of action by linking target genes, disease genes and pharmacogenes using gene interaction networks. We construct pathways for over a hundred drugs, and show that the genes included in our pathways (1) co-occur with the query drug in the literature, (2) significantly overlap or are adjacent to known drug-response pathways, and (3) are adjacent to genes that are hits in genome wide association studies assessing drug response. Finally, these computed pathways suggest novel drug repositioning opportunities (e.g., statins for follicular thyroid cancer), gene-side effect associations, and gene-drug interactions. Thus, DrugRouter generates hypotheses about drug actions using systems biology data. Twit Text FOAVip Integrating systems biology sources illuminates drug action ????Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24577151 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24577151 #FOAvip English Wikipedia <ref>{{Cite pmid|24577151}}</ref> Integrating systems biology sources illuminates drug action #MMPMID24577151 Gottlieb A; Altman RB Clin Pharmacol Ther 2014[Jun]; 95 (6): 663-9 PMID24577151show ga There are significant gaps in our understanding of the pathways by which drugs act. This incomplete knowledge limits our ability to use mechanistic molecular information rationally to repurpose drugs, understand their side effects, and predict their interactions with other drugs. Here we present DrugRouter: a novel method for generating drug-specific pathways of action by linking target genes, disease genes and pharmacogenes using gene interaction networks. We construct pathways for over a hundred drugs, and show that the genes included in our pathways (1) co-occur with the query drug in the literature, (2) significantly overlap or are adjacent to known drug-response pathways, and (3) are adjacent to genes that are hits in genome wide association studies assessing drug response. Finally, these computed pathways suggest novel drug repositioning opportunities (e.g., statins for follicular thyroid cancer), gene-side effect associations, and gene-drug interactions. Thus, DrugRouter generates hypotheses about drug actions using systems biology data. äIntegrating systems biology sources illuminates drug action (epmc).pdf DeepDyve Pubget Overpricing