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10.1186/1752-0509-7-S5-S9 http://scihub22266oqcxt.onion/10.1186/1752-0509-7-S5-S9 C4029432!4029432 !24565053     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24565053 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Syst+Biol 2013 ; 7 Suppl 5 (Suppl 5 ): S9 Nephropedia Template TP {{tp|p=24565053 |t=2013. PREAL: prediction of allergenic protein by maximum Relevance Minimum Redundancy (mRMR) feature selection |pdf=|usr=}}{{24565053 }} gab.com Text PREAL: prediction of allergenic protein by maximum Relevance Minimum Redundancy (mRMR) feature selection JO: BMC Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=24565053 #FOAvip BACKGROUND: Assessment of potential allergenicity of protein is necessary whenever transgenic proteins are introduced into the food chain. Bioinformatics approaches in allergen prediction have evolved appreciably in recent years to increase sophistication and performance. However, what are the critical features for protein's allergenicity have been not fully investigated yet. RESULTS: We presented a more comprehensive model in 128 features space for allergenic proteins prediction by integrating various properties of proteins, such as biochemical and physicochemical properties, sequential features and subcellular locations. The overall accuracy in the cross-validation reached 93.42% to 100% with our new method. Maximum Relevance Minimum Redundancy (mRMR) method and Incremental Feature Selection (IFS) procedure were applied to obtain which features are essential for allergenicity. Results of the performance comparisons showed the superior of our method to the existing methods used widely. More importantly, it was observed that the features of subcellular locations and amino acid composition played major roles in determining the allergenicity of proteins, particularly extracellular/cell surface and vacuole of the subcellular locations for wheat and soybean. To facilitate the allergen prediction, we implemented our computational method in a web application, which can be available at http://gmobl.sjtu.edu.cn/PREAL/index.php. CONCLUSIONS: Our new approach could improve the accuracy of allergen prediction. And the findings may provide novel insights for the mechanism of allergies. Twit Text FOAVip PREAL: prediction of allergenic protein by maximum Relevance Minimum Redundancy (mRMR) feature selection ????BMC Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=24565053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24565053 #FOAvip English Wikipedia <ref>{{Cite pmid|24565053 }}</ref> PREAL: prediction of allergenic protein by maximum Relevance Minimum Redundancy (mRMR) feature selection #MMPMID24565053 Wang J ; Zhang D ; Li J BMC Syst Biol 2013[]; 7 Suppl 5 (Suppl 5 ): S9 PMID24565053 show ga BACKGROUND: Assessment of potential allergenicity of protein is necessary whenever transgenic proteins are introduced into the food chain. Bioinformatics approaches in allergen prediction have evolved appreciably in recent years to increase sophistication and performance. However, what are the critical features for protein's allergenicity have been not fully investigated yet. RESULTS: We presented a more comprehensive model in 128 features space for allergenic proteins prediction by integrating various properties of proteins, such as biochemical and physicochemical properties, sequential features and subcellular locations. The overall accuracy in the cross-validation reached 93.42% to 100% with our new method. Maximum Relevance Minimum Redundancy (mRMR) method and Incremental Feature Selection (IFS) procedure were applied to obtain which features are essential for allergenicity. Results of the performance comparisons showed the superior of our method to the existing methods used widely. More importantly, it was observed that the features of subcellular locations and amino acid composition played major roles in determining the allergenicity of proteins, particularly extracellular/cell surface and vacuole of the subcellular locations for wheat and soybean. To facilitate the allergen prediction, we implemented our computational method in a web application, which can be available at http://gmobl.sjtu.edu.cn/PREAL/index.php. CONCLUSIONS: Our new approach could improve the accuracy of allergen prediction. And the findings may provide novel insights for the mechanism of allergies. |Allergens/*immunology/metabolism [MESH] |Computational Biology/*methods [MESH] |Internet [MESH] |Intracellular Space/metabolism [MESH] |Protein Transport [MESH]PREAL: prediction of allergenic protein by maximum Relevance Minimum R(epmc).pdf DeepDyve Pubget Overpricing