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10.1016/j.jchf.2013.10.006

http://scihub22266oqcxt.onion/10.1016/j.jchf.2013.10.006
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C4028447!4028447!24720916
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suck abstract from ncbi


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pmid24720916      JACC+Heart+Fail 2014 ; 2 (2): 97-112
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  • Developing Therapies for Heart Failure with Preserved Ejection Fraction: Current State and Future Directions #MMPMID24720916
  • Butler J; Fonarow GC; Zile MR; Lam CS; Roessig L; Schelbert EB; Shah SJ; Ahmed A; Bonow RO; Cleland JG; Cody RJ; Chioncel O; Collins SP; Dunnmon P; Filippatos G; Lefkowitz MP; Marti CN; McMurray JJ; Misselwitz F; Nodari S; O?Connor C; Pfeffer MA; Pieske B; Pitt B; Rosano G; Sabbah HN; Senni M; Solomon SD; Stockbridge N; Teerlink JR; Georgiopoulou VV; Gheorghiade M
  • JACC Heart Fail 2014[Apr]; 2 (2): 97-112 PMID24720916show ga
  • The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary vascular abnormalities, end-organ involvement, and comorbidities. There remain major gaps in our understanding of HFpEF pathophysiology. To facilitate a discussion of how to proceed effectively in future with development of therapies for HFpEF, a meeting was facilitated by the FDA and included representatives from academia, industry and regulatory agencies. This document summarizes the proceedings from this meeting.
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