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10.1021/ml3002852 http://scihub22266oqcxt.onion/10.1021/ml3002852 C4027571!4027571!24900668     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (3): 323-8 Nephropedia Template TP {{tp|p=24900668|t=2013. The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity |pdf=|usr=}}{{24900668}} gab.com Text The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900668 #FOAvip The cytotoxic activities and subcellular localizations of clinically used and synthetic analogues of the anthracycline family of chemotherapeutic agents were studied. The structures of the anthracycline derivatives affected their cytotoxicity and the time required for these compounds to exert cytotoxic effects on tumor cells. Fluorescent DNA intercalator displacement experiments demonstrated that there was no correlation between the DNA intercalation properties and the cytotoxicity of the studied anthracycline derivatives. Confocal microscopy experiments indicated that structural differences led to differences in subcellular localization. All studied anthracycline derivatives were observed in lysosomes, suggesting that this organelle, which is involved in several processes leading to malignancy, may contain previously unidentified molecular targets for these antitumor agents. Twit Text FOAVip The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900668 #FOAvip English Wikipedia <ref>{{Cite pmid|24900668}}</ref> The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity #MMPMID24900668 Shaul P; Frenkel M; Goldstein E; Mittelman L; Grunwald A; Ebenstein Y; Tsarfaty I; Fridman M ACS Med Chem Lett 2013[Mar]; 4 (3): 323-8 PMID24900668show ga The cytotoxic activities and subcellular localizations of clinically used and synthetic analogues of the anthracycline family of chemotherapeutic agents were studied. The structures of the anthracycline derivatives affected their cytotoxicity and the time required for these compounds to exert cytotoxic effects on tumor cells. Fluorescent DNA intercalator displacement experiments demonstrated that there was no correlation between the DNA intercalation properties and the cytotoxicity of the studied anthracycline derivatives. Confocal microscopy experiments indicated that structural differences led to differences in subcellular localization. All studied anthracycline derivatives were observed in lysosomes, suggesting that this organelle, which is involved in several processes leading to malignancy, may contain previously unidentified molecular targets for these antitumor agents. äThe Structure of Anthracycline Derivatives Determines Their Subcellula(epmc).pdf DeepDyve Pubget Overpricing