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Novel 2-Aminobenzamides as Potential Orally Active Antithrombotic Agents #MMPMID24900559
ACS Med Chem Lett 2013[Jan]; 4 (1): 32-6 PMID24900559show ga
In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.