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10.1021/ml3004632 http://scihub22266oqcxt.onion/10.1021/ml3004632 C4027554!4027554!24900662     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (2): 297-301 Nephropedia Template TP {{tp|p=24900662|t=2013. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors |pdf=|usr=}}{{24900662}} gab.com Text Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900662 #FOAvip The indenopyrazole framework was investigated as a new class of HIF-1? inhibitors. Indenopyrazole 2l was found to most strongly inhibit the hypoxia-induced HIF-1? transcriptional activity (IC50 = 0.014 ?M) among all of the known compounds having relatively simple structures, unlike manassantins. Indenopyrazole 2l suppressed HIF-1? transcriptional activity without affecting both HIF-1? protein accumulation and HIF-1?/HIF-1? heterodimerization in nuclei under the hypoxic conditions, suggesting that 2l probably affected the transcriptional pathway induced by the HIF-1?/HIF-1? heterodimer. Twit Text FOAVip Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900662 #FOAvip English Wikipedia <ref>{{Cite pmid|24900662}}</ref> Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors #MMPMID24900662 Minegishi H; Fukashiro S; Ban HS; Nakamura H ACS Med Chem Lett 2013[Feb]; 4 (2): 297-301 PMID24900662show ga The indenopyrazole framework was investigated as a new class of HIF-1? inhibitors. Indenopyrazole 2l was found to most strongly inhibit the hypoxia-induced HIF-1? transcriptional activity (IC50 = 0.014 ?M) among all of the known compounds having relatively simple structures, unlike manassantins. Indenopyrazole 2l suppressed HIF-1? transcriptional activity without affecting both HIF-1? protein accumulation and HIF-1?/HIF-1? heterodimerization in nuclei under the hypoxic conditions, suggesting that 2l probably affected the transcriptional pathway induced by the HIF-1?/HIF-1? heterodimer. äDiscovery of Indenopyrazoles as a New Class of Hypoxia Inducible Facto(epmc).pdf DeepDyve Pubget Overpricing