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10.1021/ml300351e

http://scihub22266oqcxt.onion/10.1021/ml300351e
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C4027509!4027509!24900658
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suck abstract from ncbi


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pmid24900658      ACS+Med+Chem+Lett 2013 ; 4 (2): 259-63
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  • Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors #MMPMID24900658
  • Liu JJ; Higgins B; Ju G; Kolinsky K; Luk KC; Packman K; Pizzolato G; Ren Y; Thakkar K; Tovar C; Zhang Z; Wovkulich PM
  • ACS Med Chem Lett 2013[Feb]; 4 (2): 259-63 PMID24900658show ga
  • A new series of 7,8-disubstituted pyrazolobenzodiazepines based on the lead compound 1 have been synthesized and evaluated for their effects on mitosis and angiogenesis. Described herein is the design, synthesis, SAR, and antitumor activity of these compounds leading to the identification of R1530, which was selected for clinical evaluation.
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