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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Med+Chem+Lett 2013 ; 4 (2): 259-63 Nephropedia Template TP
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Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors #MMPMID24900658
Liu JJ; Higgins B; Ju G; Kolinsky K; Luk KC; Packman K; Pizzolato G; Ren Y; Thakkar K; Tovar C; Zhang Z; Wovkulich PM
ACS Med Chem Lett 2013[Feb]; 4 (2): 259-63 PMID24900658show ga
A new series of 7,8-disubstituted pyrazolobenzodiazepines based on the lead compound 1 have been synthesized and evaluated for their effects on mitosis and angiogenesis. Described herein is the design, synthesis, SAR, and antitumor activity of these compounds leading to the identification of R1530, which was selected for clinical evaluation.