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10.1021/ml300371t http://scihub22266oqcxt.onion/10.1021/ml300371t C4027506!4027506 !24900575     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900575 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2013 ; 4 (1 ): 132-6 Nephropedia Template TP {{tp|p=24900575 |t=2013. Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry |pdf=|usr=}}{{24900575 }} gab.com Text Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900575 #FOAvip We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole molecular scaffold. Twit Text FOAVip Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900575 #FOAvip English Wikipedia <ref>{{Cite pmid|24900575 }}</ref> Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry #MMPMID24900575 Li X ; Tu Z ; Li H ; Liu C ; Li Z ; Sun Q ; Yao Y ; Liu J ; Jiang S ACS Med Chem Lett 2013[Jan]; 4 (1 ): 132-6 PMID24900575 show ga We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole molecular scaffold. äBiological evaluation of new largazole analogues: alteration of macroc(epmc).pdf DeepDyve Pubget Overpricing