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10.1021/ml300449k http://scihub22266oqcxt.onion/10.1021/ml300449k C4027501!4027501 !24900661     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24900661 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ACS+Med+Chem+Lett 2013 ; 4 (2 ): 293-6 Nephropedia Template TP {{tp|p=24900661 |t=2013. Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema |pdf=|usr=}}{{24900661 }} gab.com Text Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900661 #FOAvip High-throughput screening and subsequent hit optimization identified 1-piperidinylbenzimidazoles, exemplified by compound 1, as TRPV4 inhibitors. Lead optimization identified potent TRPV4 blocker 19, which has good target activity and pharmacokinetic properties. Inhibitor 19 was then profiled in an in vivo rat model, demonstrating its ability to inhibit TRPV4-mediated pulmonary edema. Twit Text FOAVip Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900661 #FOAvip English Wikipedia <ref>{{Cite pmid|24900661 }}</ref> Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema #MMPMID24900661 Hilfiker MA ; Hoang TH ; Cornil J ; Eidam HS ; Matasic DS ; Roethke TJ ; Klein M ; Thorneloe KS ; Cheung M ACS Med Chem Lett 2013[Feb]; 4 (2 ): 293-6 PMID24900661 show ga High-throughput screening and subsequent hit optimization identified 1-piperidinylbenzimidazoles, exemplified by compound 1, as TRPV4 inhibitors. Lead optimization identified potent TRPV4 blocker 19, which has good target activity and pharmacokinetic properties. Inhibitor 19 was then profiled in an in vivo rat model, demonstrating its ability to inhibit TRPV4-mediated pulmonary edema. ?Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activ(epmc).pdf DeepDyve Pubget Overpricing