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10.1021/ml3003132 http://scihub22266oqcxt.onion/10.1021/ml3003132 C4027466!4027466!24900569     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (1): 103-7 Nephropedia Template TP {{tp|p=24900569|t=2013. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349 |pdf=|usr=}}{{24900569}} gab.com Text Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900569 #FOAvip Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinical development candidate 8h, GDC-0349, a potent and selective ATP-competitive inhibitor of mTOR. GDC-0349 demonstrates pathway modulation and dose-dependent efficacy in mouse xenograft cancer models. Twit Text FOAVip Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900569 #FOAvip English Wikipedia <ref>{{Cite pmid|24900569}}</ref> Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349 #MMPMID24900569 Pei Z; Blackwood E; Liu L; Malek S; Belvin M; Koehler MT; Ortwine DF; Chen H; Cohen F; Kenny JR; Bergeron P; Lau K; Ly C; Zhao X; Estrada A; Truong T; Epler JA; Nonomiya J; Trinh L; Sideris S; Lesnick J; Bao L; Vijapurkar U; Mukadam S; Tay S; Deshmukh G; Chen YH; Ding X; Friedman L; Lyssikatos JP ACS Med Chem Lett 2013[Jan]; 4 (1): 103-7 PMID24900569show ga Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinical development candidate 8h, GDC-0349, a potent and selective ATP-competitive inhibitor of mTOR. GDC-0349 demonstrates pathway modulation and dose-dependent efficacy in mouse xenograft cancer models. äDiscovery and Biological Profiling of Potent and Selective mTOR Inhibi(epmc).pdf DeepDyve Pubget Overpricing