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10.1021/ml300367f http://scihub22266oqcxt.onion/10.1021/ml300367f C4027448!4027448!24900664     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (2): 306-11 Nephropedia Template TP {{tp|p=24900664|t=2013. High-Throughput Selectivity Assays for Small-Molecule Inhibitors of ?-Catenin/T-Cell Factor Protein?Protein Interactions |pdf=|usr=}}{{24900664}} gab.com Text High-Throughput Selectivity Assays for Small-Molecule Inhibitors of -Catenin/T-Cell Factor Protein Protein Interactions JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900664 #FOAvip Two homogeneous high-throughput assays, AlphaScreen and fluorescence polarization, were established to quantify inhibitor selectivity between different protein?protein complexes. As a first case study, they have been successfully applied to the key protein?protein interactions in the downstream sites of the canonical Wnt signaling pathway. The aberrant formation of the ?-catenin/T-cell factor (Tcf) complex is the major driving force for many cancers and fibroses. Crystallographic and biochemical studies reveal that the binding modes of Tcf, E-cadherin, and adenomatous polyposis coli (APC) to ?-catenin are identical and mutually exclusive. In the present study, two highly sensitive and robust assays were established to quantitatively evaluate inhibitor selectivity between ?-catenin/Tcf, ?-catenin/E-cadherin, and ?-catenin/APC interactions. A pilot screen demonstrated the feasibility of the assays and yielded four hits for the disruption of ?-catenin/Tcf interactions. A potent and dual-selective ?-catenin/Tcf inhibitor was identified. Twit Text FOAVip High-Throughput Selectivity Assays for Small-Molecule Inhibitors of -Catenin/T-Cell Factor Protein Protein Interactions ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900664 #FOAvip English Wikipedia <ref>{{Cite pmid|24900664}}</ref> High-Throughput Selectivity Assays for Small-Molecule Inhibitors of ?-Catenin/T-Cell Factor Protein?Protein Interactions #MMPMID24900664 Zhang M; Catrow JL; Ji H ACS Med Chem Lett 2013[Feb]; 4 (2): 306-11 PMID24900664show ga Two homogeneous high-throughput assays, AlphaScreen and fluorescence polarization, were established to quantify inhibitor selectivity between different protein?protein complexes. As a first case study, they have been successfully applied to the key protein?protein interactions in the downstream sites of the canonical Wnt signaling pathway. The aberrant formation of the ?-catenin/T-cell factor (Tcf) complex is the major driving force for many cancers and fibroses. Crystallographic and biochemical studies reveal that the binding modes of Tcf, E-cadherin, and adenomatous polyposis coli (APC) to ?-catenin are identical and mutually exclusive. In the present study, two highly sensitive and robust assays were established to quantitatively evaluate inhibitor selectivity between ?-catenin/Tcf, ?-catenin/E-cadherin, and ?-catenin/APC interactions. A pilot screen demonstrated the feasibility of the assays and yielded four hits for the disruption of ?-catenin/Tcf interactions. A potent and dual-selective ?-catenin/Tcf inhibitor was identified. äHigh-Throughput Selectivity Assays for Small-Molecule Inhibitors of ?-(epmc).pdf DeepDyve Pubget Overpricing