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10.1021/ml3003567 http://scihub22266oqcxt.onion/10.1021/ml3003567 C4027362!4027362!24900669     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (3): 329-32 Nephropedia Template TP {{tp|p=24900669|t=2013. Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex |pdf=|usr=}}{{24900669}} gab.com Text Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900669 #FOAvip Metal complexes represent today an attractive class of experimental anti-Alzheimer agents with the potential of blocking ?-amyloid 1?42 aggregation and scavenging its toxicity. Three representative ruthenium(III) complexes, namely NAMI A, KP1019, and PMRU20, were specifically evaluated to this end in an established in vitro model of AD relying on primary cortical neurons. Notably, PMRU20 turned out to be highly effective in protecting cortical neurons against A? 1?42 toxicity, while the other tested ruthenium compounds were poorly active or even inactive; we also found that PMRU20 is virtually devoid of any significant toxicity in vitro at the applied concentrations. Interestingly, PMRU20 was neuroprotective even against the toxicity induced by A? 25?35. The direct reaction of PMRU20 with A? 1?42 was explored through ESI MS analysis and some adduct formation evidenced. In addition, thioflavin T assays revealed that PMRU20 greatly reduces A? 1?42 aggregation. The implications of these findings are discussed in relation to emerging treatment strategies for the Alzheimer?s disease. Twit Text FOAVip Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900669 #FOAvip English Wikipedia <ref>{{Cite pmid|24900669}}</ref> Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex #MMPMID24900669 Messori L; Camarri M; Ferraro T; Gabbiani C; Franceschini D ACS Med Chem Lett 2013[Mar]; 4 (3): 329-32 PMID24900669show ga Metal complexes represent today an attractive class of experimental anti-Alzheimer agents with the potential of blocking ?-amyloid 1?42 aggregation and scavenging its toxicity. Three representative ruthenium(III) complexes, namely NAMI A, KP1019, and PMRU20, were specifically evaluated to this end in an established in vitro model of AD relying on primary cortical neurons. Notably, PMRU20 turned out to be highly effective in protecting cortical neurons against A? 1?42 toxicity, while the other tested ruthenium compounds were poorly active or even inactive; we also found that PMRU20 is virtually devoid of any significant toxicity in vitro at the applied concentrations. Interestingly, PMRU20 was neuroprotective even against the toxicity induced by A? 25?35. The direct reaction of PMRU20 with A? 1?42 was explored through ESI MS analysis and some adduct formation evidenced. In addition, thioflavin T assays revealed that PMRU20 greatly reduces A? 1?42 aggregation. The implications of these findings are discussed in relation to emerging treatment strategies for the Alzheimer?s disease. äPromising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Comp(epmc).pdf DeepDyve Pubget Overpricing