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10.1021/ml300396r http://scihub22266oqcxt.onion/10.1021/ml300396r C4027137!4027137!24900670     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2013 ; 4 (3): 333-7 Nephropedia Template TP {{tp|p=24900670|t=2013. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator |pdf=|usr=}}{{24900670}} gab.com Text Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900670 #FOAvip A novel series of alkoxyimino derivatives as S1P1 agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure?activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylben zyl)azetidine-3-carboxylic acid (32, BAF312, Siponimod), which has recently completed phase 2 clinical trials in patients with relapsing?remitting multiple sclerosis. Twit Text FOAVip Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900670 #FOAvip English Wikipedia <ref>{{Cite pmid|24900670}}</ref> Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator #MMPMID24900670 Pan S; Gray NS; Gao W; Mi Y; Fan Y; Wang X; Tuntland T; Che J; Lefebvre S; Chen Y; Chu A; Hinterding K; Gardin A; End P; Heining P; Bruns C; Cooke N; Nuesslein-Hildesheim B ACS Med Chem Lett 2013[Mar]; 4 (3): 333-7 PMID24900670show ga A novel series of alkoxyimino derivatives as S1P1 agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure?activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylben zyl)azetidine-3-carboxylic acid (32, BAF312, Siponimod), which has recently completed phase 2 clinical trials in patients with relapsing?remitting multiple sclerosis. äDiscovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor M(epmc).pdf DeepDyve Pubget Overpricing