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10.1021/ml3003605 http://scihub22266oqcxt.onion/10.1021/ml3003605 C4027132!4027132 !24900645     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900645 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2013 ; 4 (2 ): 225-9 Nephropedia Template TP {{tp|p=24900645 |t=2013. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer s and Prion Diseases |pdf=|usr=}}{{24900645 }} gab.com Text A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer s and Prion Diseases JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900645 #FOAvip (E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both A? and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits A? self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test). Twit Text FOAVip A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer s and Prion Diseases ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900645 #FOAvip English Wikipedia <ref>{{Cite pmid|24900645 }}</ref> A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer s and Prion Diseases #MMPMID24900645 Staderini M ; Auli? S ; Bartolini M ; Tran HN ; González-Ruiz V ; Pérez DI ; Cabezas N ; Martínez A ; Martín MA ; Andrisano V ; Legname G ; Menéndez JC ; Bolognesi ML ACS Med Chem Lett 2013[Feb]; 4 (2 ): 225-9 PMID24900645 show ga (E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both A? and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits A? self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test). äA Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic(epmc).pdf DeepDyve Pubget Overpricing