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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Pediatr+Endocrinol+Metab
2013 ; 18
(2
): 65-70
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Comparison of the prevalence of islet autoantibodies according to age and disease
duration in patients with type 1 diabetes mellitus
#MMPMID24904854
Kong YH
; Kim MS
; Lee DY
Ann Pediatr Endocrinol Metab
2013[Jun]; 18
(2
): 65-70
PMID24904854
show ga
PURPOSE: This study investigated the prevalence of islet autoantibodies in
children and adults with T1DM according to their age and the duration of disease.
METHODS: We measured the levels of islet autoantibodies, including antiglutamic
acid decarboxylase antibody (anti-GAD Ab), and combined these with anthropometric
measurements and laboratory tests of 137 patients newly diagnosed with T1DM
during the last 20 years. The subjects were subdivided into four groups according
to their age at the onset of the disease. We then compared the prevalence of
islet autoantibodies in the different age groups with the duration of disease.
RESULTS: Among the 137 patients, 68.9% tested positive for islet autoantibodies
(71.4% within 1 year; 67.7% after 1 year of the disease onset). Within 1 year of
the onset of the disease, 66.3% of the patients were positive for the anti-GAD
Ab, and 35.6% were positive for IAAs. The prevalence of islet autoantibodies was
significantly higher in the prepubertal groups than in the postpubertal groups
(80.0% vs. 58.3%). The rate of positive islet autoantibodies changed with the
duration of disease, and it differed according to the type of autoantibody and
the age of the patient. CONCLUSION: The rates of positive islet autoantibodies
were significantly higher in younger than in older patients at the time of the
diagnosis of the disease. The positive rates were significantly changed 1 year
after the onset of the disease in the preschool and the children groups. So these
findings suggest that we need to diagnose type 1B diabetes distinguished T2DM in
aldolescent group, carefully.