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2013 ; 18
(2
): 81-4
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Sex hormone binding globulin, free estradiol index, and lipid profiles in girls
with precocious puberty
#MMPMID24904857
Chae HW
; Kwon AR
; Kim DH
; Kim HS
Ann Pediatr Endocrinol Metab
2013[Jun]; 18
(2
): 81-4
PMID24904857
show ga
PURPOSE: Sex hormone-binding globulin (SHBG) modulates the availability of
biologically active free sex hormones. The regulatory role of SHBG might be
important in the relationship between hormone levels and the modification of
lipid profiles in girls with precocious puberty. However, few studies have
evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels
in these girls. METHODS: One hundred and nine girls less than 8 years of age with
pubertal development were enrolled. FEI was calculated with SHBG and estradiol
(E2). We analyzed SHBG between peak luteinizing hormone (LH)?5 (IU/L) (group 1)
and LH<5 (IU/L) (group 2) through a gonadotropin releasing hormone stimulation
test. RESULTS: Body mass index (BMI) standard deviation score (SDS) was higher in
group 2 than in group 1 (P=0.004). Serum SHBG levels did not differ and FEI was
not higher in group 1 (P=0.122). Serum cholesterol, HDL, and LDL did not differ;
however, triglyceride levels were higher in group 2 (P=0.023). SHBG was
negatively correlated with bone age advancement, BMI, BMI SDS, and FEI, and was
positively correlated with HDL. However, SHBG was not correlated with E2 or peak
LH. CONCLUSION: Serum SHBG itself might not be associated with precocious puberty
in girls, but it might be related to BMI and lipid profiles. Further studies are
needed to reveal the relationship between sex hormone and obesity in girls with
precocious puberty.