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Different clinical courses of central precocious girls according to their age at
presentation and treatment
#MMPMID24904846
Yoon SA
; Han HS
; Kim H
; Yun SC
Ann Pediatr Endocrinol Metab
2013[Mar]; 18
(1
): 19-25
PMID24904846
show ga
PURPOSE: The progressivity of central precocious puberty (CPP) seems to depend on
the age at presentation. We evaluated the clinical courses of CPP girls according
to their age at initiation of treatment. METHODS: One hundred thirty five girls
with CPP diagnosed between Jan. 2003 and Dec. 2009 and regularly followed for
more than one year were included. They were treated with gonadotropin-releasing
hormone agonists (GnRHa) every four weeks. Subjects were divided into two groups
based on whether they were treated before (Group I, N=20) or after seven years of
age (Group II, N=115). We compared the anthropometric parameters, the predicted
adult height (PAH), predicted treatment periods, and the laboratory findings of
the two groups every six months. RESULTS: Out of 135 CPP patients, 123 were
idiopathic and twelve had neurogenic problems. At the baseline, patients' average
bone age (BA) was significantly older than chronologic age (CA) and PAH was
significantly shorter than target height (TH). BA and CA were significantly older
in group II, but the BA/CA ratio was significantly greater in group I. The
average treatment period required to overcome the CA-BA difference was 4.64 yr
(group I vs II; 7.98 yr vs 4.24 yr, P < 0.01), and the period needed to overcome
PAH-TH difference was 2.49 yr (group I vs II; 4.37 yr vs 2.32 yr, P < 0.01).
CONCLUSION: Among the girls with CPP, the younger age group had more advanced BA
than CA, and needed significantly longer treatment periods to overcome the BA-CA
gap and PAH-TH gaps.
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