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2014 ; 2014
(ä): 428619
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A novel stent coated with antibodies to endoglin inhibits neointimal formation of
porcine coronary arteries
#MMPMID24883312
Cui S
; Liu JH
; Song XT
; Ma GL
; Du BJ
; Lv SZ
; Meng LJ
; Gao QS
; Li K
Biomed Res Int
2014[]; 2014
(ä): 428619
PMID24883312
show ga
Endoglin/CD105 is an accessory protein of the transforming growth factor-?
receptor system that plays a critical role in proliferation of endothelial cells
and neovasculature. Here, we aimed to assess the effect of novel stents coated
with antibodies to endoglin (ENDs) on coronary neointima formation. Thirty ENDs,
thirty sirolimus-eluting stents (SESs), and thirty bare metal stents (BMSs) were
randomly assigned and placed in the coronary arteries in 30 juvenile pigs.
Histomorphometric analysis and scanning electron microscopy were performed after
stent implantation. Our results showed that after 7 days, there was no difference
in the neointimal area and percent area stenosis in ENDs compared with SMSs or
BMSs. After 14 days, the neointima area and percent area stenosis in ENDs were
markedly decreased than those in BMSs or SESs (P < 0.05). Moreover, the
percentage of reendothelialization was significantly higher in ENDs than that in
SESs or BMSs (P < 0.01) at 7 and 14 days. The artery injury and the inflammation
scores were similar in all groups at 7 and 14 days. In conclusion, our results
demonstrated for the first time to our knowledge that endoglin antibody-coated
stents can markedly reduce restenosis by enhancing reendothelialization in the
porcine model and potentially offer a new approach to prevent restenosis.