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10.1021/ml300192k http://scihub22266oqcxt.onion/10.1021/ml300192k C4025875!4025875!24900386     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (10): 828-33 Nephropedia Template TP {{tp|p=24900386|t=2012. Structure?Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway |pdf=|usr=}}{{24900386}} gab.com Text Structure Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900386 #FOAvip Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as agonists of Hh signaling primarily contain a single hydroxyl on the alkyl side chain. We sought to further explore how side chain hydroxylation patterns affect oxysterol-mediated Hh activation, by performing a structure?activity relationship study on a series of synthetic OHCs. The most active analogue, 23(R)-OHC (35), demonstrated potent activation of Hh signaling in two Hh-dependent cell lines (EC50 values 0.54?0.65 ?M). In addition, OHC 35 was approximately 3-fold selective for the Hh pathway as compared to the liver X receptor, a nuclear receptor that is also activated by endogenous OHCs. Finally, 35 induced osteogenic differentiation and osteoblast formation in cultured cells, indicating functional agonism of the Hh pathway. Twit Text FOAVip Structure Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900386 #FOAvip English Wikipedia <ref>{{Cite pmid|24900386}}</ref> Structure?Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway #MMPMID24900386 Corman A; DeBerardinis A; Hadden MK ACS Med Chem Lett 2012[Oct]; 3 (10): 828-33 PMID24900386show ga Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as agonists of Hh signaling primarily contain a single hydroxyl on the alkyl side chain. We sought to further explore how side chain hydroxylation patterns affect oxysterol-mediated Hh activation, by performing a structure?activity relationship study on a series of synthetic OHCs. The most active analogue, 23(R)-OHC (35), demonstrated potent activation of Hh signaling in two Hh-dependent cell lines (EC50 values 0.54?0.65 ?M). In addition, OHC 35 was approximately 3-fold selective for the Hh pathway as compared to the liver X receptor, a nuclear receptor that is also activated by endogenous OHCs. Finally, 35 induced osteogenic differentiation and osteoblast formation in cultured cells, indicating functional agonism of the Hh pathway. äStructure?Activity Relationships for Side Chain Oxysterol Agonists of (epmc).pdf DeepDyve Pubget Overpricing