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10.1021/ml300209g http://scihub22266oqcxt.onion/10.1021/ml300209g C4025817!4025817!24900409     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (11): 931-5 Nephropedia Template TP {{tp|p=24900409|t=2012. Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer s Disease |pdf=|usr=}}{{24900409}} gab.com Text Synthesis and SAR Studies of Fused Oxadiazines as -Secretase Modulators for Treatment of Alzheimer s Disease JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900409 #FOAvip Fused oxadiazines (3) were discovered as selective and orally bioavailable ?-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure?activity relationships (SARs) did not translate from the oxadiazoline to the oxadiazine series. Subsequent SAR studies on modifications at the C3 and C4 positions of the fused oxadiazine core helped to identify GSMs such as compounds 8r and 8s that were highly efficacious in vitro and in vivo in a number of animal models with highly desirable physical and pharmacological properties. Further improvements of in vitro activity and selectivity were achieved by the preparation of fused morpholine oxadiazines. The shift in specificity of APP cleavage rather than a reduction in overall ?-secretase activity and the lack of changes in substrate accumulation and Notch processing as observed in the animal studies of compound 8s confirm that the oxadiazine series of compounds are potent GSMs. Twit Text FOAVip Synthesis and SAR Studies of Fused Oxadiazines as -Secretase Modulators for Treatment of Alzheimer s Disease ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900409 #FOAvip English Wikipedia <ref>{{Cite pmid|24900409}}</ref> Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer s Disease #MMPMID24900409 Huang X; Zhou W; Liu X; Li H; Sun G; Mandal M; Vicarel M; Zhu X; Bennett C; McCraken T; Pissarnitski D; Zhao Z; Cole D; Gallo G; Zhu Z; Palani A; Aslanian R; Clader J; Czarniecki M; Greenlee W; Burnett D; Cohen-Williams M; Hyde L; Song L; Zhang L; Chu I; Buevich A ACS Med Chem Lett 2012[Nov]; 3 (11): 931-5 PMID24900409show ga Fused oxadiazines (3) were discovered as selective and orally bioavailable ?-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure?activity relationships (SARs) did not translate from the oxadiazoline to the oxadiazine series. Subsequent SAR studies on modifications at the C3 and C4 positions of the fused oxadiazine core helped to identify GSMs such as compounds 8r and 8s that were highly efficacious in vitro and in vivo in a number of animal models with highly desirable physical and pharmacological properties. Further improvements of in vitro activity and selectivity were achieved by the preparation of fused morpholine oxadiazines. The shift in specificity of APP cleavage rather than a reduction in overall ?-secretase activity and the lack of changes in substrate accumulation and Notch processing as observed in the animal studies of compound 8s confirm that the oxadiazine series of compounds are potent GSMs. äSynthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulato(epmc).pdf DeepDyve Pubget Overpricing