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10.1021/ml200278u

http://scihub22266oqcxt.onion/10.1021/ml200278u
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suck abstract from ncbi


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pmid24900444
      ACS+Med+Chem+Lett 2012 ; 3 (2 ): 151-4
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  • Heteroaromatic Moieties in the Sphingosine Backbone of ?-Galactosylceramides for Noncovalent Interactions with CD1d #MMPMID24900444
  • Kim Y ; Kim J ; Oh K ; Lee DS ; Park SB
  • ACS Med Chem Lett 2012[Feb]; 3 (2 ): 151-4 PMID24900444 show ga
  • A series of ?-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of ?-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
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