Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/ml3000534 http://scihub22266oqcxt.onion/10.1021/ml3000534 C4025795!4025795!24900505     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (7): 530-4 Nephropedia Template TP {{tp|p=24900505|t=2012. Design and Synthesis of Potent, Selective Inhibitors of Matriptase |pdf=|usr=}}{{24900505}} gab.com Text Design and Synthesis of Potent, Selective Inhibitors of Matriptase JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900505 #FOAvip Matriptase is a member of the type II transmembrane serine protease family. Several studies have reported deregulated matriptase expression in several types of epithelial cancers, suggesting that matriptase constitutes a potential target for cancer therapy. We report herein a new series of slow, tight-binding inhibitors of matriptase, which mimic the P1?P4 substrate recognition sequence of the enzyme. Preliminary structure?activity relationships indicate that this benzothiazole-containing RQAR-peptidomimetic is a very potent inhibitor and possesses a good selectivity for matriptase versus other serine proteases. A molecular model was generated to elucidate the key contacts between inhibitor 1 and matriptase. Twit Text FOAVip Design and Synthesis of Potent, Selective Inhibitors of Matriptase ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900505 #FOAvip English Wikipedia <ref>{{Cite pmid|24900505}}</ref> Design and Synthesis of Potent, Selective Inhibitors of Matriptase #MMPMID24900505 Colombo É; Désilets A; Duchêne D; Chagnon F; Najmanovich R; Leduc R; Marsault E ACS Med Chem Lett 2012[Jul]; 3 (7): 530-4 PMID24900505show ga Matriptase is a member of the type II transmembrane serine protease family. Several studies have reported deregulated matriptase expression in several types of epithelial cancers, suggesting that matriptase constitutes a potential target for cancer therapy. We report herein a new series of slow, tight-binding inhibitors of matriptase, which mimic the P1?P4 substrate recognition sequence of the enzyme. Preliminary structure?activity relationships indicate that this benzothiazole-containing RQAR-peptidomimetic is a very potent inhibitor and possesses a good selectivity for matriptase versus other serine proteases. A molecular model was generated to elucidate the key contacts between inhibitor 1 and matriptase. äDesign and Synthesis of Potent, Selective Inhibitors of Matriptase (epmc).pdf DeepDyve Pubget Overpricing