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10.1021/ml3001193 http://scihub22266oqcxt.onion/10.1021/ml3001193 C4025753!4025753!24900526     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (8): 653-7 Nephropedia Template TP {{tp|p=24900526|t=2012. Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12 |pdf=|usr=}}{{24900526}} gab.com Text Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900526 #FOAvip We describe a prodrug concept in which the target enzyme MMP12 produces its own inhibitor in a two-step activation procedure. By using an MMP12-specific peptide sequence and a known sulfonamide drug integrated in the backbone, the active inhibitor is released upon enzyme cleavage. In in vitro experiments, we present proof of concept that the activation proceeds with useful kinetics. The approach is highly selective over the closely related MMP8. If applied in vivo in the future, these prodrugs might release the active entity in a highly specific manner only at such sites where enzyme activity resides. Twit Text FOAVip Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900526 #FOAvip English Wikipedia <ref>{{Cite pmid|24900526}}</ref> Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12 #MMPMID24900526 Cobos-Correa A; Stein F; Schultz C ACS Med Chem Lett 2012[Aug]; 3 (8): 653-7 PMID24900526show ga We describe a prodrug concept in which the target enzyme MMP12 produces its own inhibitor in a two-step activation procedure. By using an MMP12-specific peptide sequence and a known sulfonamide drug integrated in the backbone, the active inhibitor is released upon enzyme cleavage. In in vitro experiments, we present proof of concept that the activation proceeds with useful kinetics. The approach is highly selective over the closely related MMP8. If applied in vivo in the future, these prodrugs might release the active entity in a highly specific manner only at such sites where enzyme activity resides. äTarget-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of M(epmc).pdf DeepDyve Pubget Overpricing