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10.1021/ml300055n

http://scihub22266oqcxt.onion/10.1021/ml300055n
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C4025743!4025743 !24900488
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suck abstract from ncbi


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pmid24900488
      ACS+Med+Chem+Lett 2012 ; 3 (5 ): 427-32
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  • RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists #MMPMID24900488
  • Kakuta H ; Yakushiji N ; Shinozaki R ; Ohsawa F ; Yamada S ; Ohta Y ; Kawata K ; Nakayama M ; Hagaya M ; Fujiwara C ; Makishima M ; Uno S ; Tai A ; Maehara A ; Nakayama M ; Oohashi T ; Yasui H ; Yoshikawa Y
  • ACS Med Chem Lett 2012[May]; 3 (5 ): 427-32 PMID24900488 show ga
  • Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates.
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