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10.1021/ml300063m http://scihub22266oqcxt.onion/10.1021/ml300063m C4025728!4025728!24900499     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (6): 484-9 Nephropedia Template TP {{tp|p=24900499|t=2012. The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes |pdf=|usr=}}{{24900499}} gab.com Text The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900499 #FOAvip A structure?activity relationship study of the imidazolyl-?-tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice. Twit Text FOAVip The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900499 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900499 #FOAvip English Wikipedia <ref>{{Cite pmid|24900499}}</ref> The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes #MMPMID24900499 He S; Ye Z; Truong Q; Shah S; Du W; Guo L; Dobbelaar P; Lai Z; Liu J; Jian T; Qi H; Bakshi RK; Hong Q; Dellureficio J; Pasternak A; Feng Z; deJesus R; Yang L; Reibarkh M; Bradley S; Holmes MA; Ball RG; Ruck RT; Huffman M; Wong F; Samuel K; Reddy VB; Mitelman S; Tong S; Chicchi GG; Tsao KL; Trusca D; Wu M; Shao Q; Trujillo M; Eiermann GJ; Li C; Zhang BB; Howard A; Zhou YP; Nargund RP; Hagmann WK ACS Med Chem Lett 2012[Jun]; 3 (6): 484-9 PMID24900499show ga A structure?activity relationship study of the imidazolyl-?-tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice. äThe Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Tre(epmc).pdf DeepDyve Pubget Overpricing