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10.1021/ml3003346 http://scihub22266oqcxt.onion/10.1021/ml3003346 C4025676!4025676 !24900432     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900432 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2012 ; 3 (12 ): 1091-6 Nephropedia Template TP {{tp|p=24900432 |t=2012. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 |pdf=|usr=}}{{24900432 }} gab.com Text Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900432 #FOAvip The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. As part of a drug discovery program targeting EZH2, we have identified highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitors, including GSK926 (3) and GSK343 (6). These compounds are small molecule chemical tools that would be useful to further explore the biology of EZH2. Twit Text FOAVip Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900432 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900432 #FOAvip English Wikipedia <ref>{{Cite pmid|24900432 }}</ref> Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 #MMPMID24900432 Verma SK ; Tian X ; LaFrance LV ; Duquenne C ; Suarez DP ; Newlander KA ; Romeril SP ; Burgess JL ; Grant SW ; Brackley JA ; Graves AP ; Scherzer DA ; Shu A ; Thompson C ; Ott HM ; Aller GS ; Machutta CA ; Diaz E ; Jiang Y ; Johnson NW ; Knight SD ; Kruger RG ; McCabe MT ; Dhanak D ; Tummino PJ ; Creasy CL ; Miller WH ACS Med Chem Lett 2012[Dec]; 3 (12 ): 1091-6 PMID24900432 show ga The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. As part of a drug discovery program targeting EZH2, we have identified highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitors, including GSK926 (3) and GSK343 (6). These compounds are small molecule chemical tools that would be useful to further explore the biology of EZH2. äIdentification of Potent, Selective, Cell-Active Inhibitors of the His(epmc).pdf DeepDyve Pubget Overpricing